74274-66-1

Upstream product

• 109-01-3 1-methyl-piperazine 
• 79286-73-0 1-ethyl-1,4-dihydro-4-oxo-6-fluoro-7-chloro-1,8-naphthyridine-3-carboxylic acid 
• 50-00-0 formaldehyd 
• 74011-58-8 enoxacine 
• 64-18-6 formic acid 
• 87938-98-5 C₁₉H₂₃N₆O₄⁽¹⁺⁾*F₆P^(1-) 
• 87939-04-6 7-(4-Acetyl-piperazin-1-yl)-1-ethyl-6-nitro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 87938-96-3 7-(4-Acetyl-piperazin-1-yl)-6-amino-1-ethyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 54132-41-1 ethyl 7-(4-acetyl-1-piperazinyl)-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 56654-05-8 ethyl 7-chloro-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 82671-13-4 ethyl 7-(4-acetyl-1-piperazinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 84233-60-3 ethyl 7-(4-acetyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 87939-09-1 1-ethyl-6-fluoro-1,4-dihydro-7-hydroxy-4-oxo-1,8-naphthyridine-3-carboxylic acid 

Relevant academic research and scientific papers

N-methyl enoxacin aldehyde thiosemicarbazone derivatives as well as preparation method and application thereof

The invention discloses N-methyl enoxacin aldehyde thiosemicarbazone derivatives as well as a preparation method and an application thereof. The derivatives have the general structural formula shown in a formula I in the specification, wherein a substituent group R is H atom or hydrocarbonyl containing 1-5 carbon atoms. According to the N-methyl enoxacin aldehyde thiosemicarbazone derivatives, three advantageous pharmacophores including fluoronaphthalene quinacridone frameworks, imine-containing Schiff base and thiourea are spliced, so that the antitumor activity of the novel compound is improved and the toxic and side effects on normal cells are reduced. The derivatives can serve as an antitumor active substance for development of an antitumor drug with a brand-new structure.

N-methyl enoxacin aldehyde-4-aryl thiosemicarbazide derivative, and preparation method and application thereof

The invention discloses an N-methyl enoxacin aldehyde-4-aryl thiosemicarbazide derivative, and a preparation method and application thereof. The N-methyl enoxacin aldehyde-4-aryl thiosemicarbazide derivative has a structure formula as shown in formula (1), wherein Ar is a phenyl group, a substituted phenyl group, a pyridyl group, a furan group or a thienyl group. According to the N-methyl enoxacin aldehyde-4-aryl thiosemicarbazide derivative disclosed by the invention, the combination of three advantaged pharmacophores, including fluorine naphthyridine ketone framework, Schiff base imine and thiourea can be realized, so that the anti-tumor activity of the new compound can be increased and the toxic and side effects to normal cells can be reduced. The N-methyl enoxacin aldehyde-4-aryl thiosemicarbazide derivative can be used as an anti-tumor active substance for developing an anti-tumor drug with a brand new structure.

N-methyl enoxacin (rhodanine unsaturated ketone) amide derivative, preparation method and applications thereof

The invention discloses a N-methyl enoxacin (rhodanine unsaturated ketone) amide derivative, a preparation method and applications thereof, wherein the chemical structure general formula represented by the following formula I is used, and in the formula I, Ar is a benzene ring or a substituted benzene ring or a furan ring or a pyridine ring. According to the present invention, the N-methyl enoxacin (rhodanine unsaturated ketone) amide derivative achieves the combination of the four pharmacophores such as the naphthyridinone skeleton, the amide, the rhodanine and alpha,beta-unsaturated ketone so as to increase the anti-tumor activity of the new compound and reduce the toxic-side effects on normal cells, such that the N-methyl enoxacin (rhodanine unsaturated ketone) amide derivative can be adopted as the anti-tumor active substance so as to develop the anti-tumor drug having the completely-new structure.

Pyridonecarboxylic acids as antibacterial agents. 2. Synthesis and structure-activity relationships of 1,6,7-trisubstituted 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids, including enoxacin, a new antibacterial agent

The title compounds having nitro, amino, cyano, chloro, or fluoro as the C-6 substituent were prepared. Introduction of the chloro and cyano groups at C-6 was accomplished by the Sandmeyer reaction of 6-amino-1,8-naphthyridine derivatives via their 6-diaz

Novel naphthyridine derivatives, intermediates thereof, processes for preparation thereof, and use thereof

This invention relates to 1,8-naphthyridine compounds of the formula STR1 wherein X is a halogen atom especially fluorine atom, R1 is an ethyl group or a vinyl group, and R2 is a hydrogen atom or a lower alkyl group, their salts and processes for the preparation of them. The 1,8-naphthyridine compounds and their salts are useful as antibacterial agents and intermediates thereof.