79289-25-1

Usage

Uses

Used in Pharmaceutical Industry:
Butanoic acid, 4-chloro-, 2-(diphenylmethylene)hydrazide is used as an anti-tuberculosis agent for its potential to combat various strains of the tuberculosis bacterium. Its hydrazide nature and 4-chloro substitution contribute to its promising activity against this infectious disease.
Used in Agrochemical Industry:
In the agrochemical sector, Butanoic acid, 4-chloro-, 2-(diphenylmethylene)hydrazide is used as a herbicide candidate. It has demonstrated inhibitory activity against certain types of plants, indicating its potential as a selective weed control agent. However, further research is required to fully understand its applications and potential risks in this field.

Upstream product

• 5350-57-2 benzophenone hydrazone 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 119-61-9 benzophenone 

Downstream Products

• 79289-48-8 1-<(diphenylmethylene)amino>pyrrolidin-2-one 

Relevant academic research and scientific papers

POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES

The current invention provides urea derivatives, in particular compounds having the core structure heteroaryl-NH-CO-NH-aryl-O- heteroaryl, for use in treating, ameliorating, delaying, curing and/ or preventing a disease or condition associated with muscle cells and/or satellite cells, such as Duchenne muscular dystrophy, Becker muscular dystrophy, cachexia or sarcopenia.

Synthesis and properties of 3-oxo-1,2-diazetidinium ylides

Treatment of α-chloroacylhydrazones of diaryl and certain aralkyl and dialkyl ketones with sodium hydride in anhydrous tetrahydrofuran gives 1-(disubstituted methylene)-3-oxo-1,2-diazetidinium inner salts (ylides). The reaction pathway involves formation of the hydrazone anion followed by intramolecular SN2 halide displacement (with complete inversion at the α carbon) by the sp2 imine nitrogen. These 1-(disubstituted methylene)-3-oxo-1,2-diazetidinium ylides are reduced by sodium borohydride to give 1-substituted 1,2-diazetidin-3-ones, undergo dipolar cycloaddition reactions to give fused aza-β-lactams, and can be hydrolyzed with p-toluenesulfonic acid monohydrate to the p-toluenesulfonic acid salt of 1,2-diazetidinone.