792920-01-5

Upstream product

• 863222-41-7 (3E,2'S,3'R,5'Z,8'S,9'R)-4-{(8'-benzyloxy-9'-benzyloxymethyl-2'-vinyl-2',3',4',7',8',9'-hexahydrooxonin-3'-yl)oxy}-5-(tert-butyldimethylsilyloxy)-2-(trimethylsilyloxy)pent-3-enenitrile 
• 792919-87-0 methyl (2E,2'S,3'R,5'Z,8'S,9'R)-3-{(8'-benzyloxy-9'-benzyloxymethyl-2'-vinyl-2',3',4',7',8',9'-hexahydrooxonin-3'-yl)oxy}-4-(tert-butyldimethylsilyloxy)-2-butenoate 
• 792920-00-4 (2E,2'S,3'R,5'Z,8'S,9'R)-3-{(8'-benzyloxy-9'-benzyloxymethyl-2'-vinyl-2',3',4',7',8',9'-hexahydrooxonin-3'-yl)oxy}-4-(tert-butyldimethylsilyloxy)-2-butenol 
• 792919-91-6 (2E,2'S,3'R,5'Z,8'S,9'R)-4-{(8'-benzyloxy-9'-benzyloxymethyl-2'-vinyl-2',3',4',7',8',9'-hexahydrooxonin-3'-yl)oxy}-5-(tert-butyldimethylsilyloxy)-2-pentenol 
• 792919-90-5 (2E,2'S,3'R,5'Z,8'S,9'R)-4-{(8'-benzyloxy-9'-benzyloxymethyl-2'-vinyl-2',3',4',7',8',9'-hexahydrooxonin-3'-yl)oxy}-5-(tert-butyldimethylsilyloxy)pent-2-enenitrile 
• 792919-88-1 (2E,2'S,3'R,5'Z,8'S,9'R)-3-{(8'-benzyloxy-9'-benzyloxymethyl-2'-vinyl-2',3',4',7',8',9'-hexahydrooxonin-3'-yl)oxy}-4-(tert-butyldimethylsilyloxy)-2-butenal 
• 792919-97-2 (1R,3S,4R,6Z,9S,11R)-4-(tert-butyldimethylsilyloxy)-3-hydroxymethyl-11-phenyl-2,10,12-trioxabicyclo[7.4.0]tridec-6-ene 
• 792919-86-9 (2S,3R,5Z,8S,9R)-8-benzyloxy-9-benzyloxymethyl-2-vinyl-2,3,4,7,8,9-hexahydrooxonin-3-ol 
• 792919-96-1 (2R,3S,5Z,8R,9S)-8-(tert-butyldimethylsilyloxy)-2-hydroxymethyl-9-vinyl-2,3,4,7,8,9-hexahydrooxonin-3-ol 
• 475641-59-9 (Z)-(2R,4aR,6S,7R,11aS)-7-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononene 
• 100-39-0 benzyl bromide 
• 863222-43-9 (2S,3R,2'S,3'R,5'Z,8'S,9'R)-4-{(8'-benzyloxy-9'-benzyloxymethyl-2'-vinyl-2',3',4',7',8',9'-hexahydrooxonin-3'-yl)oxy}-5-(tert-butyldimethylsilyloxy)-2,3-epoxypentanol 
• 863222-42-8 (2E,2'S,3'R,5'Z,8'S,9'R)-4-{(8'-benzyloxy-9'-benzyloxymethyl-2'-vinyl-2',3',4',7',8',9'-hexahydrooxonin-3'-yl)oxy}-5-(tert-butyldimethylsilyloxy)-2-pentenal 
• 792919-92-7 (3R,2'S,3'R,5'Z,8'S,9'R)-4-{(8'-benzyloxy-9'-benzyloxymethyl-2'-vinyl-2',3',4',7',8',9'-hexahydrooxonin-3'-yl)oxy}-5-(tert-butyldimethylsilyloxy)pent-1-en-3-ol 

Relevant academic research and scientific papers

Synthesis of the EF-ring segment of ciguatoxin CTX1B based on novel regioselective reduction of unsaturated cyanohydrins and ring-closing olefin metathesis

Aiming at a convergent total synthesis of ciguatoxin CTX1B, its EF-ring segment has been synthesized. During the synthesis, a novel method for the construction of branched ethers, based on regioselective reduction of γ-alkoxy β,γ-unsaturated α-silyloxy ni

Novel branched ether formation via conjugate reduction of an unsaturated cyanohydrin derivative and its synthetic application to the EF-ring segment of ciguatoxin

A novel branched ether formation reaction was developed and applied to the synthesis of the EF-ring segment of ciguatoxin.