79302-77-5 Usage
General Description
The chemical 5-(3-hydroxyphenyl)-1,3,4-oxadiazol-2(3H)-one is a heterocyclic compound with a structure containing a 1,3,4-oxadiazole ring and a hydroxyphenyl group. It is commonly used as a pharmaceutical intermediate and has potential applications in medicinal chemistry. 5-(3-hydroxyphenyl)-1,3,4-oxadiazol-2(3H)-one has been found to exhibit various biological activities, including antifungal, anti-inflammatory, and antimicrobial properties. Its unique structural features make it a valuable building block for the synthesis of novel organic compounds with potential pharmaceutical benefits. Additionally, research on this chemical has shown promise in the development of new drugs and bioactive compounds for various therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 79302-77-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,3,0 and 2 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 79302-77:
(7*7)+(6*9)+(5*3)+(4*0)+(3*2)+(2*7)+(1*7)=145
145 % 10 = 5
So 79302-77-5 is a valid CAS Registry Number.
79302-77-5Relevant articles and documents
Substitution of terminal amide with 1H-1,2,3-triazole: Identification of unexpected class of potent antibacterial agents
Bi, Fangchao,Ji, Shengli,Venter, Henrietta,Liu, Jingru,Semple, Susan J.,Ma, Shutao
supporting information, p. 884 - 891 (2018/02/15)
3-Methoxybenzamide (3-MBA) derivatives have been identified as novel class of potent antibacterial agents targeting the bacterial cell division protein FtsZ. As one of isosteres for the amide group, 1,2,3-triazole can mimic the topological and electronic features of the amide, which has gained increasing attention in drug discovery. Based on these considerations, we prepared a series of 1H-1,2,3-triazole-containing 3-MBA analogues via isosteric replacement of the terminal amide with triazole, which had increased antibacterial activity. This study demonstrated the possibility of developing the 1H-1,2,3-triazole group as a terminal amide-mimetic element which was capable of both keeping and modulating amide-related bioactivity. Surprisingly, a different action mode of these new 1H-1,2,3-triazole-containing analogues was observed, which could open new opportunities for the development of antibacterial agents.
