79302-77-5

Usage

Uses

Used in Pharmaceutical Industry:
5-(3-hydroxyphenyl)-1,3,4-oxadiazol-2(3H)-one is used as a pharmaceutical intermediate for the development of new drugs and bioactive compounds. Its unique structural features and biological activities contribute to its potential applications in medicinal chemistry.
Used in Antifungal Applications:
5-(3-hydroxyphenyl)-1,3,4-oxadiazol-2(3H)-one is used as an antifungal agent, leveraging its ability to inhibit the growth of various fungi, which can be beneficial in treating fungal infections.
Used in Anti-inflammatory Applications:
5-(3-hydroxyphenyl)-1,3,4-oxadiazol-2(3H)-one is used as an anti-inflammatory agent, potentially reducing inflammation and associated symptoms, making it a candidate for the treatment of inflammatory conditions.
Used in Antimicrobial Applications:
5-(3-hydroxyphenyl)-1,3,4-oxadiazol-2(3H)-one is used as an antimicrobial agent, exhibiting properties that can inhibit the growth of bacteria, which may be useful in combating bacterial infections.
Used in Drug Development:
5-(3-hydroxyphenyl)-1,3,4-oxadiazol-2(3H)-one is used in the research and development of new therapeutic agents, as its biological activities and structural features show promise in creating effective treatments for various diseases and conditions.

Upstream product

• 75-44-5 phosgene 
• 5818-06-4 3-hydroxybenzoic hydrazide 
• 70799-63-2 3-(trimethylsiloxy)benzoyl chloride 
• 228419-14-5 5-(3-benzyloxyphenyl)-1,3,4-oxadiazol-2-one 
• 228419-13-4 3-(benzyloxy)benzoic acid hydrazide 
• 61535-46-4 3-benzyloxy-benzoyl chloride 
• 69026-14-8 3-benzyloxybenzoic acid 
• 99-06-9 3-Carboxyphenol 
• 3782-84-1 3-trimethylsiloxybenzoic acid trimethylsilyl ester 
• 79302-70-8 2-(3-trimethylsiloxyphenyl)-4-trimethylsilyl-1,3,4-oxadiazol-5-one 

Relevant academic research and scientific papers

Substitution of terminal amide with 1H-1,2,3-triazole: Identification of unexpected class of potent antibacterial agents

3-Methoxybenzamide (3-MBA) derivatives have been identified as novel class of potent antibacterial agents targeting the bacterial cell division protein FtsZ. As one of isosteres for the amide group, 1,2,3-triazole can mimic the topological and electronic features of the amide, which has gained increasing attention in drug discovery. Based on these considerations, we prepared a series of 1H-1,2,3-triazole-containing 3-MBA analogues via isosteric replacement of the terminal amide with triazole, which had increased antibacterial activity. This study demonstrated the possibility of developing the 1H-1,2,3-triazole group as a terminal amide-mimetic element which was capable of both keeping and modulating amide-related bioactivity. Surprisingly, a different action mode of these new 1H-1,2,3-triazole-containing analogues was observed, which could open new opportunities for the development of antibacterial agents.

Syntheses and Reactions of (Trimethylsiloxy)benzoyl Chlorides

The (trimethylsiloxy)benzoyl chlorides 1-7 are easily to obtain under mild conditions from silylated hydroxybenzoic acids by means of thionyl chloride.Whereas these acid chlorides are stable at room temperature, they undergo condensation polymerisation at temperatures above 100 deg C.Reactions with various nucleophils, such as thioalcohols, phenols, amines, N,O-bis(silylated)amino acids and N-silylated lactams were investigated.With hexamethyldisilazane and thionyl chloride the (trimethylsiloxy)benzonitriles 21, 22 are accessible, and by means of trimethylsilylazide the (trimethylsiloxy)phenyl isocyanates 23-25 were obtained.Conversion with phenyl carbazate and subsequent silylation lead to the 2-(trimethylsiloxy)phenyl-1,3,4-oxadiazol-5-ones 27a-c.