79324-79-1

Upstream product

• 77-78-1 dimethyl sulfate 
• 99-93-4 4-Hydroxyacetophenone 
• 2887-72-1 1-(3,5-dibromo-4-hydroxyphenyl)ethan-1-one 
• 74-88-4 methyl iodide 

Downstream Products

• 4073-35-2 3,5-dibromo-4-methoxybenzoic acid 
• 13670-73-0 3,5-dibromo-4-methoxyphenol 
• 1063635-43-7 (2E)-1-(3,5-dibromo-4-methoxyphenyl)-3-(3-bromophenyl)-2-propen-1-one 
• 1063635-63-1 (2E)-1-(3,5-dibromo-4-methoxyphenyl)-3-(4-chlorophenyl)-2-propen-1-one 
• 1063635-45-9 (2E)-1-(3,5-dibromo-4-methoxyphenyl)-3-(2-chlorophenyl)-2-propen-1-one 
• 1063635-64-2 (2E)-1-(3,5-dibromo-4-methoxyphenyl)-3-(3-nitrophenyl)-2-propen-1-one 
• 1063635-62-0 C₁₆H₁₂Br₂O₃ 
• 1063635-51-7 (2E)-1-(3,5-dibromo-4-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one 
• 1063635-59-5 C₁₆H₁₂Br₂O₃ 
• 1063635-48-2 (2E)-1-(3,5-dibromo-4-methoxyphenyl)-3-(4-(N,N-dimethylamino)phenyl)-2-propen-1-one 
• 1063635-53-9 (2E)-1-(3,5-dibromo-4-methoxyphenyl)-3-(2-nitrophenyl)-2-propen-1-one 
• 1219101-98-0 C₁₆H₁₃Br₂NO₂ 
• 1007893-78-8 (3,5-dibromo-4-hydroxyphenyl)(9H-pyrido[3,4-b]indol-1-yl)methanone 
• 1007893-79-9 (6-bromo-9H-pyrido[3,4-b]indol-1-yl)(3,5-dibromo-4-hydroxyphenyl)methanone 

Relevant academic research and scientific papers

Synthesis and antibacterial activities of cadiolides A, B and C and analogues

The one-pot multicomponent synthesis of natural butenolides named cadiolides A, B, C and analogues has been realized. The antibacterial structure activity relationship shows that the presence of phenolic hydroxyl groups and the number and position of bromine atoms on the different aromatic rings are important features for antibacterial activity, besides it was demonstrated the tolerance of both benzene and furan ring at position 3 of the butenolide nucleus. Furthermore, none of the most relevant antibacterial compounds showed any cytotoxicity in freshly isolated human neutrophils.

Total synthesis and biological activity of marine alkaloid eudistomins Y1-Y7 and their analogues

Eudistomin Y class compounds are a series of β-carbolines which was originally isolated from a marine turnicate or ascidian near the South Korea Sea. These compounds contain bromo-substituted groups, which is one of the typical characters of marine natural products. We report herein the chemical synthesis and biological evaluation of seven new β-carboline-based metabolites, Eudistomins Y1-Y7, and their hydroxyl-methylated phenyl derivatives. Using bromo-substituted tryptamines and bromo-substituted phenylglyoxals as the key intermediates, Eudistomins Y 1-Y7 and their derivatives were synthesized via the acid-catalyzed Pictet-Spengler reaction and fully characterized by 1H- and 13C-NMR and mass spectroscopy. Biological studies revealed that all of the compounds showed moderate growth inhibitory activity against breast carcinoma cell line MDA-231 with IC50 of 15-63 μM and the inhibitory activities of hydroxyl-methylated phenyl products were higher than that of the corresponding natural products Eudistomins Y 1-Y7.