79325-10-3Relevant academic research and scientific papers
Synthesis of 4-alkyl (aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres as nonsteroidal cardiotonic agents
Abadi, Ashraf,Al-Deeb, Omar,Al-Afify, Ahmed,El-Kashef, Hassan
, p. 195 - 201 (2007/10/03)
Thirty new 1,2-dihydropyridine derivatives of the general formula 4-alkyl (aryl)-6-aryl-3-cyano-2(1H)-pyridinones (1-15) and 4-alkyl (aryl)-6-aryl-3-cyano-2(1H)-iminopyridines (16-30) were synthesized using one-pot multicomponent reactions of the properly substituted acetophenone, appropriate aldehyde, ammonium acetate and ethyl cyanoacetate (1-15) or malononitrile (16-30) in ethanol. These target compounds (1-30) were evaluated for their cardiotonic activity using the spontaneously beating atria model, from reserpine-treated guinea pigs. The best pharmacological profile was obtained with 3-cyano-6-(3,4-dimethoxyphenyl)-4-(4-hydroxyphenyl)-2(1H)-pyridinone (9) which displayed selectivity for increasing the force of contraction (108.7 ± 6.7,% change over control) rather than the frequency rate (40.8 ± 5.3,% change over control) at a 5 x 10-4 M concentration. The effects of structural changes upon activity are reported.
Pyridines and 5H-Benzopyranopyridines Derived from Halochalcones
Latif, N.,Mishriky, N.,Haggag, B.,Basyouni, W.
, p. 1230 - 1234 (2007/10/02)
The halochalcones (1a-c) react with malononitrile in the presence of ammonium acetate to give the corresponding 2-amino-4,6-diaryl-3-cyano-pyridines (2a-c), whereas with ethyl cyanoacetate the 4,6-diaryl-3-cyano-2-pyridones (3a-c) are obtained.On the cont
