79341-85-8Relevant academic research and scientific papers
Nickel-catalyzed direct electrochemical cross-coupling between aryl halides and activated alkyl halides
Durandetti, Muriel,Nedelec, Jean-Yves,Perichon, Jacques
, p. 1748 - 1755 (1996)
The electrochemical reduction of a mixture of aryl halides and activated alkyl halides in DMF in the presence of catalytic amount of NiBr2bipy leads to cross-coupling products in good to high yields. The method applies to the synthesis of α-aryl ketones, α-aryl esters, and allylated compounds from readily available organic halides. Optimization of the process has been obtained by slowly adding the most reactive organic halide (usually the activated alkyl halide) during the electrolysis which is best conducted at 70 °C when aryl bromides are involved.
A novel method of arylation of α-chloroketones
Durandetti,Sibille,Nedelec,Perichon
, p. 145 - 151 (2007/10/02)
α-Arylated ketones were obtained in moderate to good yields by one-step electroreductive coupling of α-chloroketones and arylhalides in DMF and in the presence of a Al- or Zn-sacrificial anode and a catalytic amount of a nickel complex.
The Allopolarization Principle and its Applications, IV. Substituent Effects in the Methylation of Enolate Anions
Gompper, Rudolf,Vogt, Hans-Hubert
, p. 2866 - 2883 (2007/10/02)
The ratio of O- and C-methylated products in the reaction of the sodium salts of acetophenones 1, propiophenones 3, phenylacetones 5, β-dicarbonyl compounds 12, α-cyanocarbonyl compounds 13, acetaldehyde, propionaldehyde, and diethylketone with dimethyl sulfate, methyl iodide, and trimethyl phosphate in HMPTA has been determined with regard to the effect of substituents.In some cases the influence of solvents, concentration and temperature has also been studied.
