79359-40-3

Upstream product

• 2700-22-3 Benzylidenemalononitrile 
• 108-98-5 thiophenol 
• 109-77-3 malononitrile 
• 100-52-7 benzaldehyde 
• 943723-80-6 2-amino-4-phenyl-6-phenylsulfanyl-1,4-dihydropyridine-3,5-dicarbonitrile 

Downstream Products

• 67720-42-7 2-hydroxy-6-amino-4-phenylpyridine-3,5-dicarbonitrile 
• 312313-29-4 2-amino-6-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-4-phenyl-pyridine-3,5-dicarbonitrile 
• 119022-76-3 2-amino-4-phenyl-6-(phenylthio)pyridine-3,5-dicarbonitrile 
• 312313-31-8 2-amino-6-{2-[2-(2-chloro-ethoxy)-ethoxy]-ethoxy}-4-phenyl-pyridine-3,5-dicarbonitrile 
• 312313-30-7 toluene-4-sulfonic acid 2-{2-[2-(6-amino-3,5-dicyano-4-phenyl-pyridin-2-yloxy)-ethoxy]-ethoxy}-ethyl ester 
• 1353985-80-4 2-(1,3-diphenylprop-2-ynylamino)-4-phenyl-6-(phenylthio)pyridine-3,5-dicarbonitrile 
• 1353985-83-7 3-benzyl-2,7-diphenyl-5-(phenylthio)imidazo[1,2-a]pyridine-6,8-dicarbonitrile 
• 127236-33-3 4-phenyl-2-sulfanylpyridine-3,5-dicarbonitrile 
• 1353657-36-9 4-phenyl-2-(phenylsulfanyl)pyridine-3,5-dicarbonitrile 
• 189278-39-5 2-amino-6-(2-oxo-2-phenylethylsulfanyl)-4-phenylpyridine-3,5-dicarbonitrile 
• 1353656-49-1 4-{[(3,5-dicyano-4-phenylpyridin-2-yl)sulfanyl]methyl}-N-methylpyridine-2-carboxamide 
• 160684-40-2 5-amino-4-phenyl-2-phenylsulfanyl-6,7,8,9-tetrahydrobenzo[b][1,8]-naphthyridine-3-carbonitrile 

Relevant academic research and scientific papers

Discovery of Highly Potent Adenosine A1Receptor Agonists: Targeting Positron Emission Tomography Probes

Adenosine receptor (AR) radiotracers for positron emission tomography (PET) have provided knowledge on the in vivo biodistribution of ARs in the central nervous system (CNS), which is of therapeutic interest for various neuropsychiatric disorders. Additio

Synthesis, in vitro and in silico screening of 2-amino-4-aryl-6-(phenylthio) pyridine-3,5-dicarbonitriles as novel α-glucosidase inhibitors

Inhibition of α-glucosidase enzyme is of prime importance for the treatment of diabetes mellitus (DM). Apart of many organic scaffolds, pyridine based compounds have previously been reported for wide range of bioactivities. The current study reports a series of pyridine based synthetic analogues for their α-glucosidase inhibitory potential assessed by in vitro, kinetics and in silico studies. For this purpose, 2-amino-4-aryl-6-(phenylthio)pyridine-3,5-dicarbonitriles 1–28 were synthesized and subjected to in vitro screening. Several analogs, including 1–3, 7, 9, 11–14, and 16 showed many folds increased inhibitory potential in comparison to the standard acarbose (IC50 = 750 ± 10 μM). Interestingly, compound 7 (IC50 = 55.6 ± 0.3 μM) exhibited thirteen-folds greater inhibition strength than the standard acarbose. Kinetic studies on most potent molecule 7 revealed a competitive type inhibitory mechanism. In silico studies have been performed to examine the binding mode of ligand (compound 7) with the active site residues of α-glucosidase enzyme.

Natural dolomitic limestone-catalyzed synthesis of benzimidazoles, dihydropyrimidinones, and highly substituted pyridines under ultrasound irradiation

Natural dolomitic limestone (NDL) is employed as a heterogeneous green catalyst for the synthesis of medicinally valuable benzimidazoles, dihydropyrimidinones, and highly functionalized pyridines via C–N, C–C, and C–S bond formations in a mixture of ethan

Application of novel and reusable Fe3O4@CoII(macrocyclic Schiff base ligand) for multicomponent reactions of highly substituted thiopyridine and 4H-chromene derivatives

In this research study we designed and synthesized CoII(macrocyclic Schiff base ligand containing 1,4-diazepane) immobilized on Fe3O4 nanoparticles as a novel, recyclable, and heterogeneous catalyst. The nanomaterial was f

WEB (water extract of banana): An efficient natural base for one-pot multi-component synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines

One-pot multi-component synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines derivatives using WEB (water extract of banana peels ash) as a green catalyst is described. A variety of aromatic aldehydes (with electron-donating and electron-withdrawing groups) in conjunction with aromatic and aliphatic thiols are known to tolerate this reaction condition using WEB. The reaction has simple work up procedure without using toxic solvents.

Unique role of 2-hydroxyethylammonium acetate as an ionic liquid in the synthesis of Fe3O4 magnetic nanoparticles and preparation of pyridine derivatives in the presence of a new magnetically recyclable heterogeneous catalyst

Abstract: In this paper, 2-hydroxyethylammonium acetate (2-HEAA) was used as the first functionalized ionic liquid for the facile, economical and environmentally friendly synthesis of Fe3O4 nanoparticles by a co-precipitation method. The synthesized Fe3O4 nanoparticles were used as solid material for supporting 2-HEAA (Fe3O4-2-HEAA). The newly prepared Fe3O4-2-HEAA was characterized by TEM, XRD, FT-IR, TGA and elemental analysis and successfully applied as a magnetically recyclable heterogeneous catalyst for the efficient one-pot, three-component synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines. The catalyst was easily separated by an external magnet and reused at least five times without significant degradation in the activity.

Method for synthesizing polysubstituted pyridine compounds at room temperature

The invention discloses a method for synthesizing polysubstituted pyridine compounds at the room temperature. The method is technically characterized in that ethanediamine/trinitromethane eutectoid isadopted as a catalyst, an ethanol aqueous solution is t

Polysubstituted pyridine derivative and preparation method and application thereof

The invention discloses a polysubstituted pyridine derivative and a preparation method and the application thereof. The polysubstituted pyridine derivative adopts a structural formula 5. The preparation method comprises the following steps: in an organic

Synthesis, Reactions and Antitumor Activity of Certain 1,3-diphenylpyrazole-4-carboxaldehyde Derivatives

IN activity continuation especially of our the interest antitumor in synthesis activity.In of novel this paper heterocycles we have with discussed anticipat

System and method for preparing 6-mercapto polysubstituted pyridine derivative through three-component one-pot reaction

The invention discloses a system and method for preparing a 6-mercapto polysubstituted pyridine derivative through a three-component one-pot reaction, belonging to the technical field of organic synthesis. The preparation system for the 6-mercapto polysubstituted pyridine derivative comprises a raw material mixing device, a microwave reaction device, a suction filtration device, a washing device and a vacuum drying device which are sequentially arranged, wherein the microwave reaction device is used for a microwave heating reaction of raw materials in the raw material mixing device; the suction filtration device is used for suction filtration of a reaction product; the washing device and the vacuum drying device are used for washing and vacuum drying of a filter residue obtained after filtering, respectively. According to the invention, aromatic aldehydes, malononitrile and mercapto compounds are used as reaction materials, and the 6-mercapto polysubstituted pyridine derivative is prepared under the catalysis of an alkaline ionic liquid catalyst. The catalyst used in the invention is high in catalytic activity and low in usage amount and cyclic loss; and the prepared derivate has high yield and high purity.