79368-82-4

Upstream product

• 98-50-0 p-aminophenylarsonic acid 
• 7647-01-0 hydrogenchloride 
• 1122-90-3 4-aminophenylarsenoxide 

Downstream Products

• 861788-38-7 (4-amino-phenyl)-(phenylcarbamoyl-methyl)-arsinic acid 
• 1122-90-3 4-aminophenylarsenoxide 

Relevant academic research and scientific papers

Organoarsenic compound and use thereof

The invention discloses an organoarsenic compound. The organoarsenic compound has the following structural formula as shown in the specification, wherein n is 1 or 2; R, R1, R2, R3, R4 and R5 are respectively and independently amino, R6-CO-NH, R7-CO-O, alkyl, aryl, a heterocyclic substituent, alkoxyl, alkylamino, a halogen atom, nitro, hydroxyl or a hydrogen atom; R6 is alkyl, aminoalkyl or aryl;R7 is alkyl, aminoaryl or aryl. The organoarsenic compound has good inhibitory activity for thioredoxin reductase, has strong cytotoxicity for tumor cell HL-60, and can be used for preparing a thioredoxin reductase inhibitor or an antitumor drug with thioredoxin reductase as a target spot.

ANTI-CANCER AGENT

An anti-cancer agent is provided comprising a tumour homing peptide having, or having been modified to present, two cysteine residues, with an arsenic atom between, such that the tumour homing peptide cyclises to give an arsenic- containing anti-cancer agent. This allows for selection of an appropriate tumour homing peptide for treatment of a given cancer whereby the subsequent agent provides for a more targeted delivery of arsenic to the tumour microenvironment.