79409-10-2Relevant academic research and scientific papers
Synthesis of indoles using (N-arylaminomethyl)diphenylphosphine oxides
Zorgdrager, Jan,Broekhof, Nico L. J. M.,Gen, Arne van der
, p. 441 - 444 (2007/10/02)
A new route for the synthesis of 1,3-disubstituted indoles, based on (N-arylaminomethyl)-diphenylphosphine oxide (1) chemistry, is described.Adducts 2, obtained by addition of the carbanions from 1 to aldehydes, were treated with p-toluenesulfonic acid to form the desired indoles 4 in good yields, without isolation of the intermediate amino ketones 3.
