79412-41-2Relevant academic research and scientific papers
AN EFFICIENT AND INEXPENSIVE RESOLUTION OF THE POTENT DOPAMINERGIC SUBSTANCE 3-(3-HYDROXYPHENYL)-N-(1-PROPYL)-PIPERIDINE (+/-)-3-PPP
Law, Ho,Leclerc, Gerard A.,Neumeyer, John L.
, p. 989 - 992 (1991)
A new convenient and inexpensive resolution of the dopaminergic agonist (+/-)-3-PPP is described.
PHENYL-AZACYKLOALKANES
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, (2008/06/13)
Compound of the formula STR1 wherein n is 1 or 2, Y is OH, R 1 COO--, R 2 R 3 NCOO--or R 4 O whereby R 1 is an alkyl group, or a possibly substituted phenyl group, R 2 is an alkyl, phenethyl, or benzyl or phenyl group, R 3 is H or an alkyl group and R 4 i
PHENYL-AZACYCLOALKANES AND USE THEREOF IN TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
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, (2008/06/13)
Compound of the formula STR1 wherein n is 1 or 2, Y is OH, R 1 COO--, R 2 R 3 NCOO--or R 4 O whereby R 1 is an alkyl group, or a possibly substituted phenyl group, R 2 is an alkyl, phenethyl, or benzyl or phenyl group, R 3 is H or an alkyl group and R 4 i
SUBSTITUTED PHENYL PIPERIDINES
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, (2008/06/13)
Compounds of the formula wherein n is 1 or 2, Y is OH, R1COO-,R2R3NCOO-or R4O whereby R1 is an alkyl group, or a possibly substituted phenyl group, R2 is an alkyl, phenethyl,benzyl or phenyl group, R3 is H or an alkyl group and R4 is an allyl or benzyl gr
3-Phenylpiperidines. Central Dopamine-Autoreceptor Stimulating Activity
Hacksell, Uli,Arvidsson, Lars-Erik,Svensson, Uno,Nilsson, J. Lars G.
, p. 1475 - 1482 (2007/10/02)
Thirty compounds related to the selective dopamine-autoreceptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine have been synthesized and tested for central dopamine-autoreceptor stimulating activity.The 3-(3-hydroxyphenyl)piperidine moiety seems indispensable for high potency and selectivity.Introduction of an additional hydroxyl group into the 4-position of the aromatic ring gives a compound with dopaminergic activity but lacking selectivity for autoreceptors. 3-(3-Hydroxyphenyl)-N-n-propylpyrrolidine, 3-(3-hydroxy)-N-n-propylperhydroazepine, and 3-(3-hydroxyphenyl)quinuclidine were all inactive.The most potent compounds were the N-isopropyl-, N-n-butyl-, N-n-pentyl-, and N-phenethyl-substituted 3-(3-hydroxyphenyl)piperidine derivatives.None of the compounds investigated seemed to have central noradrenaline- or serotonin-receptor stimulating activity.
