85976-54-1Relevant academic research and scientific papers
A Concise Enantioselective Synthesis of (S)-Preclamol via Asymmetric Catalytic Negishi Cross-Coupling Reaction
Zhou, Yun,Liu, Chunxiao,Wang, Lifeng,Han, Leng,Hou, Shicong,Bian, Qinghua,Zhong, Jiangchun
, p. 860 - 862 (2019/04/25)
A novel, concise, and efficient enantioselective synthesis of (S)-preclamol (87% ee, 51% total yield) has been developed. The key steps of this synthetic approach included cobalt-catalyzed asymmetric catalytic cross-coupling of α-bromo ester with arylzinc and the reduction of chiral ester to diol with a tertiary carbon atom. Moreover, it was demonstrated that our enantioselective Negishi cross-coupling was a powerful tool to construct stereogenic benzylmethyl center in chiral drugs on a gram scale.
Highly active catalysts of bisphosphine oxides for asymmetric Heck reaction
Hu, Jian,Lu, Yunpeng,Li, Yongxin,Zhou, Jianrong
, p. 9425 - 9427 (2013/10/01)
Bisphosphine oxides formed highly active asymmetric Heck catalysts, which were applied in asymmetric synthesis of pharmacologically active azacycles. Olefin insertion proceeded via cis pathways, different from P,N-ligands.
AN EFFICIENT AND INEXPENSIVE RESOLUTION OF THE POTENT DOPAMINERGIC SUBSTANCE 3-(3-HYDROXYPHENYL)-N-(1-PROPYL)-PIPERIDINE (+/-)-3-PPP
Law, Ho,Leclerc, Gerard A.,Neumeyer, John L.
, p. 989 - 992 (2007/10/02)
A new convenient and inexpensive resolution of the dopaminergic agonist (+/-)-3-PPP is described.
AN EFFICIENT RESOLUTION OF 3-PPP AND ASSIGMENT OF THE ABSOLUTE CONFIGURATION
Arnold, Wolf,Daly, John J.,Imhof, Rene,Kyburz, Emilio
, p. 343 - 346 (2007/10/02)
(+/-)-3-PPP has been resolved by means of (+)- and (-)-2,2'-(1,1'-binaphtyl)phosphoric acid (BNPPA) in high optical purity; (+)-3-PPP has been assigned the R configuration on the basis of a single crystal X-ray analysis.
