79421-39-9

Usage

Uses

Used in Medicinal Chemistry:
4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzonitrile is used as a potential candidate in medicinal chemistry for its diverse biological activities, which are characteristic of spirocyclic compounds. Its unique structure allows for exploration in drug development, where it may contribute to the discovery of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzonitrile serves as a valuable building block for the synthesis of more complex molecules. Its aromatic ring and nitrile functional group provide opportunities for further chemical reactions and modifications, expanding its utility in creating novel organic compounds.
Used in Drug Development:
4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzonitrile is utilized in drug development as a starting material or intermediate in the synthesis of pharmaceutically relevant molecules. Its specific chemical and physical characteristics, once determined through experimental analysis, could reveal properties that make it suitable for the treatment or management of various diseases and conditions.
The precise applications and effectiveness of 4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzonitrile in these areas will depend on ongoing research and the outcomes of experimental studies that delve into its specific properties and interactions with biological systems.

Upstream product

• 1194-02-1 4-fluorobenzonitrile 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 584-08-7 potassium carbonate 
• 623-00-7 4-bromobenzenecarbonitrile 

Downstream Products

• 340756-87-8 4-(4-oxo-1-piperidin-1-yl)benzamide 
• 197446-34-7 4-(4-oxo-piperidin-1-yl)-benzoic acid 
• 214759-76-9 4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-benzylamine 
• 1449429-05-3 2-amino-6-(4-cyanophenyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbonitrile 
• 1449428-72-1 2,4-dichloro-N-(3-cyano-6-(4-cyanophenyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-5-(morpholinosulfonyl)benzamide 
• 79421-46-8 4-(4-oxo-piperidin-1-yl)-benzonitrile 

Relevant academic research and scientific papers

ANTI-INFECTIVE COMPOUNDS

The present invention relates to small molecule compounds and their use in the treatment of bacterial infections, in particular Tuberculosis.

Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF

Peptidoglycan is an essential component of the bacterial cell wall, and enzymes involved in its biosynthesis represent validated targets for antibacterial drug discovery. MurF catalyzes the final intracellular peptidoglycan biosynthesis step: the addition of D-Ala-D-Ala to the nucleotide precursor UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP (or L-Lys). As MurF has no human counterpart, it represents an attractive target for the development of new antibacterial drugs. Using recently published cyanothiophene inhibitors of MurF from Streptococcus pneumoniae as a starting point, we designed and synthesized a series of structurally related derivatives and investigated their inhibition of MurF enzymes from different bacterial species. Systematic structural modifications of the parent compounds resulted in a series of nanomolar inhibitors of MurF from S. pneumoniae and micromolar inhibitors of MurF from Escherichia coli and Staphylococcus aureus. Some of the inhibitors also show antibacterial activity against S. pneumoniae R6. These findings, together with two new co-crystal structures, represent an excellent starting point for further optimization toward effective novel antibacterials.

An improved synthesis of N-aryl and N-heteroaryl substituted piperidones

An efficient Pd(0)-catalyzed protocol for the rapid and efficient preparation of N-aryl and N-heteroaryl substituted piperidones is described. The two step syntheses proceed with an overall yield of 50-70% using X-Phos as optimal ligand for the Pd(0)-cata

SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL) BENZOHETEROARYL COMPOUNDS

This invention is directed to an (aminoiminomethyl or aminomethyl) benzoheteroaryl compound of formula I which is useful for inhibiting the activity of Factor Xa by combining said compound with a composition containing Factor Xa. The present invention is also directed to compositions containing compounds of the formula I, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.

Two-directional photoinduced electron transfer in a trichromophoric system

Competition bewtween electron transfer via a through σ-bond and a through π-bond mechanism has been studied in 1-(4-cyanophenyl)-4-(cyanomethylene)piperidine. In this trichromophoric system designed in a configuration acceptor-donor-acceptor, where the do

Cyclic urea derivatives, pharmaceutical compositions containing these compounds and methods of using the same

The invention relates to cyclic urea derivatives of general formula STR1 wherein Ra, Rb, X and Y are as defined herein, pharmaceutical compositions containing the derivatives and processes for preparing them.

Pyrazolo(4,3-c)quinolines

There are disclosed compounds of the formula STR1 wherein the various substituents are defined hereinbelow, and, by virtue of their ability to inhibit interleukin 1, their use as antiinflammatory agents and in treatment of disease states involving enzymat