197446-34-7

Upstream product

• 79421-39-9 4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-benzonitrile 
• 1022929-13-0 C₁₆H₂₃NO₄ 
• 79421-38-8 4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-benzoic acid ethyl ester 
• 340756-74-3 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)benzoic acid 

Downstream Products

• 340756-95-8 dibenzyl 1-[4-(4-oxo-1-piperidinyl)benzoyl]-L-glutamate 
• 340756-93-6 ethyl 1-[4-(4-oxo-1-piperidinyl)benzoyl]-L-valinate 
• 391906-34-6 4-Methyl-(2S)-2-[4-(4-oxo-piperidin-1-yl)-benzoylamino]-pentanoic acid methyl ester 
• 221360-84-5 (S)N[5-(4-Methylpiperazin-1-yl)-3,4-dihydro-2H-1-benzopyran-3-yl]-4-(4-piperidon-1-yl)benzamide 
• 1022929-15-2 C₂₃H₃₄N₂O₄ 
• 340757-08-6 [butyl(4-{4-[(2R)-2-hydroxy-2-(4-hydroxy-3-methanesulfonylaminophenyl)ethylamino]piperidin-1-yl}benzoyl)amino]acetic acid ethyl ester 
• 340757-00-8 methyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-phenylalaninate 
• 340756-99-2 ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-leucinate 
• 340756-98-1 ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-valinate 
• 340756-97-0 methyl 1-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-prolinate 
• 340756-96-9 ethyl [(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)amino]acetate 

Relevant academic research and scientific papers

HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE

Compounds of formula (I), and salts, N-oxides, hydrates and solvates thereof are histone deacetylase inhibitors and are useful in the treatment of cell proliferative diseases, including cancers: wherein Q, V and W independently represent -N= or -C=; B is

Substituted chroman derivatives

The present invention relates to new new piperidyl or piperazinyl-substituted dihydro-2H-1-benzopyran derivatives compound having the formula (I) wherein X is N or CH; Y is NR2CH2, CH2NR2, NR2CO, CONR

(4-Piperidin-1-yl)phenyl amides: Potent and selective human β3 agonists

In search of potent and selective human β3 agonists as potential drugs for the treatment of human obesity and type II diabetes, a series of (4-piperidin-1-yl)phenyl amides was prepared and evaluated for their biological activity on the human β

Substituted 1,2,3,4-tetrahydronaphthalene derivatives

PCT No. PCT/SE97/00469 Sec. 371 Date Apr. 25, 1997 Sec. 102(e) Date Apr. 25, 1997 PCT Filed Mar. 20, 1997 PCT Pub. No. WO97/34883 PCT Pub. Date Sep. 25, 1997New piperidinyl- or piperazinyl-substituted-1,2,3,4-tetrahydronaphthalene derivatives having the formula wherein X is N or CH; Y is NR2CH2, CH2-NR2, NR2-CO, CO-NR2 or NR2SO2; R1is H, C1-C6 alkyl or C3-C6 cycloalkyl; R3 is C1-C6 alkyl, C3-C6 cycloalkyl or (CH2)n-aryl, where aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted; n is 0-4; as (R)-enantiomer, (S)-enantiomer or a racemate in the form of the free base or a pharmaceutically acceptable salt or hydrate thereof; a pharmaceutical formulation containing the compounds, use of the compounds in the treatment of 5-hydroxytryptamine mediated disorders, processes for the preparation of the compounds and intermediates for the preparation of the compounds.

Combination of a 5-HT reuptake inhibitor and a H5-HT1B anatagonist or partial agonist

PCT No. PCT/SE98/01601 Sec. 371 Date Oct. 21, 1998 Sec. 102(e) Date Oct. 21, 1998 PCT Filed Sep. 9, 1998 PCT Pub. No. WO99/13877 PCT Pub. Date Mar. 25, 1999The invention relates to a combination of a first component (a) which is a 5-HT reuptake inhibitor

Combination of a selective 5-HT1A antagonist and a selective h5-HT1B antagonist or partial agonist

PCT No. PCT/SE98/01600 Sec. 371 Date Oct. 21, 1998 Sec. 102(e) Date Oct. 21, 1998 PCT Filed Sep. 9, 1998 PCT Pub. No. WO99/13876 PCT Pub. Date Mar. 25, 1999The invention relates to a combination of a first component (a) which is a selective 5-HT1A recepto