79422-73-4

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-2-(3-BROMOPHENYL)ACETIC ACID is used as a reagent for the synthesis of substituted 2-aminoimidazole-4-ones, which are compounds with potential therapeutic applications in the treatment of cognitive impairment, Alzheimer's disease, neurodegeneration, and dementia. These imidazole-4-ones are believed to modulate key signaling pathways and target enzymes involved in these neurological disorders, offering a promising avenue for the development of novel therapeutic agents.

InChI:InChI=1/C8H8BrNO2/c9-6-3-1-2-5(4-6)7(10)8(11)12/h1-4,7H,10H2,(H,11,12)

Upstream product

• 2835-06-5 phenylglycin 
• 7440-44-0 pyrographite 
• 79422-72-3 5-(3-Bromphenyl)hydantoin 
• 773837-37-9 sodium cyanide 
• 3132-99-8 m-bromobenzoic aldehyde 

Downstream Products

• 79422-87-0 N-[1-(3-Bromo-phenyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-4-methyl-benzenesulfonamide 
• 79422-88-1 N-[1-(3-Bromo-phenyl)-2-oxo-2-piperidin-1-yl-ethyl]-4-methyl-benzenesulfonamide 
• 79423-00-0 N-[1-(3-Cyano-phenyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-4-methyl-benzenesulfonamide 
• 79422-86-9 N-[1-(3-Bromo-phenyl)-2-morpholin-4-yl-2-oxo-ethyl]-4-methyl-benzenesulfonamide 
• 79423-01-1 N-[1-(3-Cyano-phenyl)-2-oxo-2-piperidin-1-yl-ethyl]-4-methyl-benzenesulfonamide 
• 79423-13-5 3-[2-Oxo-2-pyrrolidin-1-yl-1-(toluene-4-sulfonylamino)-ethyl]-thiobenzamide 
• 79422-89-2 Naphthalene-2-sulfonic acid [1-(3-bromo-phenyl)-2-morpholin-4-yl-2-oxo-ethyl]-amide 
• 79422-99-4 N-[1-(3-Cyano-phenyl)-2-morpholin-4-yl-2-oxo-ethyl]-4-methyl-benzenesulfonamide 
• 79423-14-6 3-[2-Oxo-2-piperidin-1-yl-1-(toluene-4-sulfonylamino)-ethyl]-thiobenzamide 
• 79423-12-4 3-[2-Morpholin-4-yl-2-oxo-1-(toluene-4-sulfonylamino)-ethyl]-thiobenzamide 
• 79423-15-7 3-[2-Morpholin-4-yl-1-(naphthalene-2-sulfonylamino)-2-oxo-ethyl]-thiobenzamide 
• 79446-79-0 3-[2-Oxo-2-pyrrolidin-1-yl-1-(toluene-4-sulfonylamino)-ethyl]-benzamidine; hydriodide 
• 79446-80-3 3-[2-Oxo-2-piperidin-1-yl-1-(toluene-4-sulfonylamino)-ethyl]-benzamidine; hydriodide 
• 79423-26-0 3-[2-Oxo-2-pyrrolidin-1-yl-1-(toluene-4-sulfonylamino)-ethyl]-thiobenzimidic acid methyl ester; hydriodide 

Relevant academic research and scientific papers

Efficient access to (1H)-isoindolin-1-one-3-carboxylic acid derivatives by orthopalladation and carbonylation of methyl arylglycinate substrates

The orthopalladation of methyl arylglycinate derivatives has been studied. The reaction proceeds efficiently for different electron-withdrawing and electron-releasing substituents at the aryl ring. The carbonylation of the orthopalladated complexes affords, in a single step, substituted (1H)-isoindolin-1-one-3-carboxylates. These compounds constitute valuable synthetic intermediates and can be transformed diastereoselectively into octahydroisoindole-1-carboxylic acid derivatives, an important scaffold in the synthesis of many biologically active compounds.

SPIRO-CONDENSED IMIDAZOLONE DERIVATIVES INHIBITING THE GLYCINE TRANSPORTER

Compounds of formula (I) and salts thereof are provided: formula (I), wherein the groups are as defined in the specification. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.

Chemistry of unprotected amino acids in aqueous solution: Direct bromination of aromatic amino acids with bromoisocyanuric acid sodium salt under strong acidic condition

Brominations of unprotected aromatic amino acids such as phenylalanine, tyrosine, and glycine, with bromoisocyanuric acid mono sodium salt (BICA-Na) were conducted in 60% aq. H2SO4 at 0°C to give a mixture of mono-brominated products in good yield. Unexpectedly, meta-bromophenylglycine was obtained as main product accompanied by ortho- and para-substituted products, while phenylalanine gave only ortho- and para-substituted products. Bromination of 2-phenylethylamine or benzylamine showed a tendency similar to the corresponding amino acids.

Carboxylic acid amides having antithrombotic activity

Compounds with antithrombotic activity and factor Xa-inhibiting activity of the general formula: Exemplary are: (1) (L)-2-(5-carbamimidoyl-2-hydroxy-phenyl)-N-[3-methyl-4-(2-aminocarbonyl-pyrrolidin-1-yl-carbonyl)-phenyl]-acetamide, (2) 2-(5-carbamimidoyl

Synthesis of Antiproteolytically Active Nα-Arylsulphonylated Amidinophenylglycinamides

Several Nα-arylsulphonylated p- and m-amidinophenylglycinamides were prepared for the purpose of testing their efficacy as serine proteinase inhibitors.These compounds were obtained from the bromophenylhydantoins 1 and 2 via the bromophenylglycines 3 and