79430-99-2

Upstream product

• 105-07-7 4-cyanobenzaldehyde 
• 1571-08-0 methyl 4-formylbenzoate 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 117390-07-5 (E)-4-(methoxycarbonyl)cinnamic acid 
• 75-05-8 acetonitrile 
• 619-44-3 methyl 4-iodobenzoate 
• 107-13-1 acrylonitrile 

Downstream Products

• 74733-36-1 methyl 4-(2-cyanoethyl)benzoate 
• 67146-57-0 1,1'-dibenzyl-1,4,1',4'-tetrahydro-[4,4']bipyridinyl-3,3'-dicarboxylic acid diamide 
• 74733-38-3 3-(4-methoxycarbonylphenyl)propylamine 
• 1397226-28-6 methyl 4-(3-(2,2,2-trifluoroacetamido)propyl)benzoate 

Relevant academic research and scientific papers

Manganese(I)-Catalyzed H-P Bond Activation via Metal-Ligand Cooperation

Here we report that chiral Mn(I) complexes are capable of H-P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal-ligand cooperation, a strategy previously not considered for catalytic H-P bond activation, is at the base of the mechanistic action of the Mn(I)-based catalyst. Our computational studies support a stepwise mechanism for the hydrophosphination and provide insight into the origin of the enantioselectivity.

HISTONE DEACETYLASE INHIBITORS

Provided herein are isoform selective histone deacetylase inhibitors of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, metabolites, prodrugs, solvates, pharmaceutically acceptable salts and compositions thereof. These compounds are isoform selective inhibitors of HDACs and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as cancer, malignant tumors, autoimmune diseases, skin diseases, fungal infections, protozoal infections, HIV, inflammation and CNS disorders.

Efficient nickel catalyst for coupling of acetonitrile with aldehydes

A Ni complex of a diarylamido-based PNP ligand is an efficient and robust catalyst for coupling of acetonitrile with aldehydes. The Royal Society of Chemistry 2005.

Novel stereoselective synthesis of (E)-cinnamonitriles via Heck arylation of acrylonitrile catalysed by a silica-supported bidentate arsine palladium(0) complex

(E)-Cinnamonitriles have been synthesised stereoselectively in high yields via Heck arylation of acrylonitrile with aryl iodides catalysed by a silica-supported bidentate arsine palladium(O) complex. This polymeric palladium(0) complex can be recovered and reused without noticeable loss of activity.

Stereoselective synthesis of (E)-cinnamonitriles via heck arylation of acrylonitrile and aryl iodides in water

Heck arylation of acrylonitrile and aryl iodides were carried out in the presence of catalytic amounts of Pd(OAc)2 and Bu4NBr in neat water and a variety of substituted (E)-cinnamonitriles were obtained in good yields under mild cond

Redox-Photosensitized Reactions. 11. Ru(bpy)32+-Photosensitized Reactions of 1-Benzyl-1,4-dihydronicotinamide with Aryl-Substituted Enones, Derivatives of Methyl Cinnamate, and Substituted Cinnamonitriles: Electron-Transfer Mechanism and Structure-Reactivity Relationship

Reactions of 1-benzyl-1,4-dihydronicotinamide (BNAH) with aryl-substituted enones and derivatives of methyl cinnamate and cinnamonitrile (1a-u) are photosensitized by Ru(bpy)32+ (bpy = 2,2'-bipyridine).The reduction of carbon-carbon double bonds commonly requires the substitution of either an electron-withdrawing aryl group or two phenyl groups at the β-carbon atom of 1.With enones which possess one aryl substituent with no extra electron-withdrawing group at the β position, the photosensitized reactions result in no two-electron reductions but give 1:1 adducts (4d-h) along with half-reduced dimers of olefins (3d and 3g) and a half-oxidized dimer of BNAH (5).The observed results can be easily interpreted by assuming the intervention of 1-benzyl-3-carbamoyl-1,4-dihydropyridin-4-yl radical (BNA.) and half-reduced species (.1-H) as key intermediates that are formed by mediated electron-proton transfer from BNAH to 1 in which Ru(bpy)32+ acts as a one-electron shuttle upon photoexcitation in the initial electron transfer.Whether BNA. undergoes electron transfer to or a radical-coupling reaction with .1-H depends on steric and electronic properties of .1-H which should be affected by the substituents at the radical center.Mechanistic implications for thermal reactions of NADH models with olefins in the dark are briefly discussed on the basis of these observations.