79434-97-2Relevant academic research and scientific papers
Biomimetic chromanol cyclisation: A common route to a-tocotrienol and α-tocopherol
Chapelat, Julien,Chougnet, Antoinette,Woggon, Wolf-D.
experimental part, p. 2069 - 2076 (2009/09/08)
A common synthetic route to a-tocotrienol and a-tocopherol has been accomplished by a biomimetic cyclisation that yields the chromanol ring. The chirality at C2 of the chro- manol was induced by a covalently attached chiral dipeptide. Its terminal Asp participates in the enantioface-selective pro-tonation of the double bond of the a-tocotrienol precursor. a-Tocotrienol was diastereoselectively hydrogenated to a-tocopherol.
Determination of the stereoisomers of racemic α-tocopherol in pharmaceutical preparations by high-performance liquid chromatography and gas chromatography
Klaczkow, Gabriela,Anuszewska, Elzbieta L.
experimental part, p. 715 - 721 (2009/07/25)
In the present study we used chiral high performance liquid chromatography and gas chromatography to determine the stereoisomers of racemic α-tocopherol. The Chiralcel OD-H and Silar-100 AT columns were used. Statistical evaluation of the results established the precision of these methods.
