794525-93-2

Upstream product

• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 24424-99-5 di-tert-butyl dicarbonate 
• 26055-05-0 N-[N-(tert-butoxycarbonyl)-L-leucyl]-L-phenylalanine 
• 135130-98-2 (4R)-4-{1-[(S)-(tert-butoxycarbonyl)amino]-2-phenylethyl}-γ-butyrolactone 
• 59793-76-9 2-(4-bromophenyl)-2-phenyl-1,3-dioxolane 
• 338462-91-2 3-carbethoxy-5(R)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>dihydrofuran-2(3H)-one 
• 41418-67-1 4-(2-phenyl-1,3-dioxolan-2-yl)benzaldehyde 
• 115416-38-1 N-(5-aminopentyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazole-4-yl)pentanamide 
• 794525-91-0 (1S-(4-(4R-benzoyl-benzyl)-5-oxo-tetrahydrofuran-2-yl)-2R-phenylethyl)carbamic acid tert-butyl ester 
• 1027947-47-2 (2R,4R,5S)-2-(4-Benzoyl-benzyl)-5-tert-butoxycarbonylamino-4-hydroxy-6-phenyl-hexanoic acid 
• 794525-84-1 tert-butyl (S)-(1-((R)-4-(2-phenyl-1,3-dioxolan-2-yl)benzylidene)-tetrahydro-5-oxofuran-2-yl)-2-phenylethylcarbamate 
• 794525-86-3 tert-butyl (S)-(1-((2R,4R)-4-(2-phenyl-1,3-dioxolan-2-yl)benzyl)-tetrahydro-5-oxofuran-2-yl)-2-phenylethylcarbamate 

Relevant academic research and scientific papers

Stereoselective synthesis of photoreactive peptidomimetic γ-secretase inhibitors

The first asymmetric synthesis of novel, potent photoreactive γ-secretase inhibitors 2 and 3 has been accomplished. Two Stereoselective methods for the preparation of lactone 9 are described. Protected benzophenone intermediate 19 is prepared via an aldol-elimination reaction followed by a PtO2-catalyzed asymmetric hydrogenation. Two routes leading from 19 to compounds 2 and 3 are evaluated. The application of 3 as an activity-based probe has been demonstrated by localizing γ-secretase activity in the plasma membrane of intact cells.