794529-77-4Relevant academic research and scientific papers
The synthesis of distamycin analog containing phosphonyl group
Ye, Yong,Zhong, Shang-Bin,Liu, Ruo-Yu,Cao, Li-Feng,Liu, Cun-Jiang,Yang, Jun-Liang,Zhao, Yu-Fen
, p. 2251 - 2257 (2007)
In order to obtain high biological activity compound, a series of distamycin analog containing phosphonyl group were synthesized by chloroform reaction and coupling reaction using DCC/HOBT as promoting additives.
Synthesis and cytotoxicity of pyrrole-amino acid dipeptides containing phosphonyl group
Liu, Ruo-Yu,Ye, Yong,Yang, Jun-Liang,Liu, Cun-Jiang,Zhao, Yu-Fen
experimental part, p. 528 - 529 (2009/04/07)
A series of pyrrole-amino acid dipeptide were synthesised by chloroform reaction and coupling reaction using DCC/HOBT as promoting additives. The structure of compound was confirmed by 1H NMR, 31P NMR, MS and IR. The biological activity data showed that the dipeptide containing nitrogen mustard group inhibited all four cells that were examined.
Synthesis and cytotoxicity of nitrogen mustard/tripolypyrrole conjugate
Ye, Yong,Liu, Cun-Jiang,Liu, Yan-Hong,Cao, Li-Feng,Zhao, Yu-Fen
experimental part, p. 1851 - 1854 (2009/06/08)
(Chemical Equation Presented) A series of nitrogen mustard derivatives were synthesized by chloroform reaction and coupling reaction using DCC/ HOBT as promoting additives. The structure of compound was confirmed by 1H NMR, 31P NMR, MS and JR. The data show that the nitrogen mustard with tripolypyrrole as the linker inhibits all the four tested cells and has the highest activity.
Design, synthesis and in vitro cytotoxic studies of novel bis-pyrrolo[2,1][1,4] benzodiazepine-pyrrole and imidazole polyamide conjugates
Kumar, Rohtash,Lown, J. William
, p. 641 - 654 (2007/10/03)
The design, synthesis and biological evaluation of novel pyrrolo [2,1][1,4] benzodiazepine (PBD) dimers 38-43 linked with pyrrole and imidazole polyamides from either side by a flexible methylene chain of variable length are described, which involved merc
