79466-34-5Relevant academic research and scientific papers
Method for preparing amino alcohol derivative
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Paragraph 0102; 0103; 0104, (2018/11/22)
The invention provides a method for preparing an amino alcohol derivative. The method is characterized in that substitution reaction is carried out on ester groups of dihydric alcohol carboxylic esteror polyhydric alcohol carboxylic ester to obtain the amino alcohol derivative, wherein the amidogen is derived into sulfonamido, and at least one carboxylic ester group remains. The method for preparing the amino alcohol derivative has the advantages that the raw materials are cheap and obtained easily, the use quantity of catalysts is low, the reaction condition is simple, and the selectivity ofproducts is high.
Enumeration of hydroxyl groups of sugars and sugar alcohols by aqueous-based acetylation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
Adeuya, Anthony,Price, Neil P.J.
experimental part, p. 1372 - 1376 (2012/08/08)
RATIONALE The properties of carbohydrates are determined in part by the number and stereochemical arrangement of their hydroxyl groups. To facilitate their analysis, rapid methods are needed to identify and enumerate hydroxyl groups in sugars and polyalcohols, especially methods that are water-based. METHODS The present report details the results of an alternative method for identification and enumeration of hydroxyl groups in aqueous media. It employs vinyl acetate to selectively derivatize hydroxyl groups in analytes, followed by analysis of the reaction mixtures by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry (MALDI-TOF-MS). RESULTS The method has been applied to several single and multi-component mixtures of monosaccharides and polyalcohols. The O-acetylated products were analyzed without chromatographic separation or purification by MALDI-TOF-MS. The mass spectra revealed consecutive ion peaks that are separated by 42 mass units as a consequence of displacement of one hydroxyl hydrogen by one acetyl group. CONCLUSIONS A rapid and aqueous-based method is described to enumerate the hydroxyl groups in carbohydrates. The number of ion peaks due to derivatized products is determined by MALDI-TOF-MS, and corresponds to the number of free hydroxyl groups in the analyte. The method is applicable to both single and multi-component mixtures. Published 2011. This article is a US Government work and is in the public domain in the USA. Published 2012. This article is a US Government work and is in the public domain in the USA.
Stereocontrolled Total Synthesis of the Unnatural Enantiomers of Castanospermine and 1-epi-Castanospermine
Mulzer, Johann,Dehmlow, Henrietta,Buschmann, Juergen,Luger, Peter
, p. 3194 - 3202 (2007/10/02)
A concise practical synthesis (13 steps, ca. 10-12percent overall yield) of the unnatural enantiomer of castanospermine ((-)-1) and its 1-epimer 2 from 2,3,4-tri-O-benzyl-D-xylose (3) is described.Key steps in the synthesis are two organometal aldehyde ad
