79482-00-1

Usage

InChI:InChI=1/C14H11NO3/c1-10-7-8-12(9-13(10)15(17)18)14(16)11-5-3-2-4-6-11/h2-9H,1H3

Upstream product

• 134-84-9 4-Methylbenzophenone 
• 860564-14-3 3,4'-diamino-4-methyl-5-nitro-benzophenone 
• 10397-30-5 4-methyl-3-nitrobenzoyl chloride 
• 71-43-2 benzene 
• 80500-27-2 (4-methyl-3-nitrophenyl)boronic acid 
• 98-88-4 benzoyl chloride 
• 7697-37-2 nitric acid 
• 96-98-0 4-methyl-3-nitrobenzoic acid 
• 5350-47-0 (4-methylphenyl)(4-nitrophenyl)methanone 
• 99717-09-6 4-methyl-3,4'-dinitro-benzophenone 
• 331831-18-6 4-methyl-3,5,4'-trinitro-benzophenone 
• 108-88-3 toluene 

Downstream Products

• 62261-44-3 3-amino-4-methyl-benzophenone 
• 873388-64-8 4-methyl-3,3'-dinitro-benzophenone 
• 861079-27-8 4-methyl-3,5,3'-trinitro-benzophenone 
• 119657-22-6 4-bromomethyl-3-nitrobenzophenone 
• 119657-06-6 3-nitro-4-(phenylthiomethyl)benzophenone 
• 119657-16-8 diethyl 4-benzoyl-2-nitrobenzylphosphonate 
• 119657-23-7 3-nitro-4-<1-(phenylsulfonyl)ethyl>benzophenone 
• 119657-18-0 diethyl (4-benzoyl-2-nitrophenyl)(phenylthio)methylphosphonate 
• 94514-35-9 3-nitro-4-(phenylsulfonylmethyl)benzophenone 
• 114521-66-3 5-benzoyl-isoindoline-1,3-dione 
• 3886-01-9 4-benzoyl-phthalic acid-anhydride 
• 3885-88-9 4-benzoyl-phthalic acid 
• 13209-03-5 2-benzoylanthracene-9,10-dione 
• 3885-89-0 2,5-dibenzoyl-benzoic acid 

Relevant academic research and scientific papers

Substituted diaryldiazomethanes and diazofluorenes: Structure, reactivity and stability

The synthesis of several substituted diaryldiazomethanes and diazofluorenes, and an assessment of their structure, reactivity and stability, is reported.

Palladium-catalyzed reactions of arylboron compounds with carboxylic acid chlorides

Reactions of sodium tetraarylborates and arylboronic acids with acyl chlorides in the presence of palladium salts afford non-symmetrical ketones in high yields under mild conditions.

Synthesis of unsymmetric ketones via ligandless Pd-catalyzed reaction of acyl chlorides with organoboranes

The cross-coupling reaction of sodium tetra-arylborates with acyl chlorides to give high yields of unsymmetric ketones has been carried out at 20°C in the presence of Pd(OAc)2 and Na2CO3 in dry or aqueous acetone. Under aqueous conditions arylboronic acids react smoothly with benzoyl chloride resulting in substituted benzophenones.

Utility of Complementary Molecular Reactivity and Molecular Recognition (CMR/R) Technology and Polymer-Supported Reagents in the Solution-Phase Synthesis of Heterocyclic Carboxamides

The use of our recently reported chemical library purification strategy in the development of a herbicidal lead, N-(3-benzoylphenyl)-3-(1,1-dimethylethyl)-1-methyl-1H-pyrazole-5-carboxamide (3), is described. The approach applying fundamental properties of complementary molecular reactivity and molecular recognition (CMR/R) as the basis for a general purification strategy was utilized. Polymeric reagents were used in the synthesis to generate reactive species involved in product formation, and complementary molecular reactivity/molecular recognition polymer 8 (CMR/R polymer 8) was used in the solution-phase syntheses of building blocks, primary libraries, and lead refinement libraries. An extension of the CMR/R methodology was applied, utilizing a sequestration enabling reagent (SER), transforming a reactant into an electrophilic species sequestrable by CMR/R polymer 8. This library purification strategy enabled rapid lead generation and lead refinement to afford herbicide 27o. The CMR/R solid-phase purification technique enabled a simple, general, and powerful protocol, eliminating the usual tedious and time-consuming methods required for solution-phase product purification. The result was the synthesis of hundreds of compounds, prepared in a relatively short time, leading to a compound with a 4-fold improvement in herbicidal activity over the initial lead.