79485-96-4

Usage

Uses

Used in Organic Synthesis:
3-bromo-2,4-dimethylthiophene is utilized as a key building block in organic synthesis for the creation of various complex organic molecules. Its unique structure and reactivity make it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Research:
In pharmaceutical research, 3-bromo-2,4-dimethylthiophene serves as a crucial intermediate for the development of new drugs. Its presence in the molecular structure can impart specific biological activities, making it a promising candidate for the synthesis of therapeutic agents targeting various diseases.
Used in Drug Discovery and Development:
3-bromo-2,4-dimethylthiophene is recognized for its potential as a building block for the synthesis of molecules with biological activity. This makes it a valuable compound in drug discovery and development, where it can be used to create novel therapeutic agents with improved efficacy and selectivity.
Used in the Synthesis of Bioactive Molecules:
As a halogenated derivative of 2,4-dimethylthiophene, 3-bromo-2,4-dimethylthiophene is employed in the synthesis of bioactive molecules. Its incorporation into molecular structures can enhance the pharmacological properties of the resulting compounds, contributing to the advancement of new treatments for various medical conditions.

Upstream product

• 638-00-6 2,4-dimethylthiophene 
• 6030-36-0 4-methylthiophene-2-carbaldehyde 
• 616-44-4 3-Methylthiophene 
• 63862-00-0 2,4-dibromo-3,5-dimethylthiophene 

Downstream Products

• 503308-96-1 2,4-dimethylthiophene-3-carboxylic acid 
• 63826-85-7 (2,4-dimethylthiophen-3-yl)methanol 
• 936502-36-2 4-[2-(2,4-dimethyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopenten-1-yl]-3,5-dimethylthiophene 

Relevant academic research and scientific papers

1,3-bicyclo[1.1.1]pentanediyl: The shortest rigid linear connector of phenylated photochromic units and a 1,5-dimethoxy-9,10-di(phenylethynyl) anthracene fluorophore

An excess of bis-1,3-(4-iodophenyl)bicyclo[1.1.1]pentane, prepared in 63% yield by iodination of 1.3-diphenylbicyclo[1.1.1]pentane, was selectively mono-coupled with 9-ethynyl-1,5-dimethoxy-10-phenylethynylanthracene (26), and subsequently with the zinc derivatives of 1-(2-methyl/methoxy-4-methyl-5- phenylthiophen-3-yl)-2-(2-methyl/methoxy-4-methylthiophen-3-yl) perfluorocyclopentenes (38-H-41-H). Regioselective synthesis of the 2-unsubslituted thiophenes 38-H-41-H required intermediate prepara tion of 2-trimethylsilyl-3,5-dimethyl-4-bromothiophene (37) or 2-trimethylsilyl-5- methoxy-3-methyl-4-bromothiophene (40). Protection of the α-position of the thiophene ring with a 2-trimethylsilyl group blocks the rearrangement of the 4-lithio derivatives into the corresponding 2-lithiated thiophenes. With the bicyclo[1.1.1]pentane frag ment linking the photochromic units 1-3 and 1,5-dimethoxy-9,10-di(phenylethynyl)anthracene as a fluorescent part, quantitative resonance energy transfer between the excited state of the fluorophore (donor) and the closed form of the photochromic units 1-3 (acceptors) was observed. The closed forms of the methoxy-substituted photochromic units 2 and 3 are less resistant to UV light (313 nm) than the closed form of 1.

Photochromism of Dithienylethenes with Electron-Donating Substituents

Bis(2,4-dimethyl-5-phenylthiophene-3-yl)perfluorocyclopentenes having hydrogen, methoxy, diethylamino, or cyano substituents at para-positions of the phenyl groups were synthesized to reveal the effect of the substitution on the absorption coefficient ε of the closed-ring forms and the photochemical reactivity.Electron-donating substituents, such as methoxy or diethylamino groups, were found to be effective to increase the absorption coefficient and to decrease the ring-opening quantum yield.The cyclization quantum yield was scarely affected by the substitution.The conversion from the open- to the closed-ring forms of the diethylamino-substituted compound in the photostationary state under irradiation with 313 nm light was close to 100percent.

Side-chain Effects on the Fragmentation Behaviour of Alkylthiophenes

The processes leading to the fragment ions formed from alkylthiophene molecule ions by benzylic cleavage without and with transfer of one hydrogen from the side-chain to the ring and the influence of additional methyl groups on the relative importance of these two fragmentation reactions were investigated.

Polyene compounds

Novel 9-substituted or unsubstituted thienyl-3,7-dimethyl-nona-2,4,6,8-tetraene derivatives, useful as antitumor agents as well as processes for their preparation and novel intermediates are disclosed.