503308-96-1

Upstream product

• 79485-96-4 3-bromo-2,4-dimethylthiophene 
• 638-00-6 2,4-dimethylthiophene 
• 6030-36-0 4-methylthiophene-2-carbaldehyde 
• 63862-00-0 2,4-dibromo-3,5-dimethylthiophene 
• 616-44-4 3-Methylthiophene 
• 78071-30-4 4-methylthiophene-3-carboxylic acid 
• 74-88-4 methyl iodide 
• 30318-99-1 3-bromo-4-methylthiophene 

Downstream Products

• 503308-97-2 5-Bromo-2,4-dimethylthiophene-3-Carboxylic Acid 
• 63826-85-7 (2,4-dimethylthiophen-3-yl)methanol 

Relevant academic research and scientific papers

SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME

The present disclosure relates to compounds of Formula (I): (I); and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as autoinflammatory and autoimmune diseases and cancers.

PYRAZOLE AMIDE DERIVATIVE

The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.