79492-50-5Relevant academic research and scientific papers
Ultrasound-promoted an efficient method for one-pot synthesis of 2-amino-4,6-diphenylnicotinonitriles in water: A rapid procedure without catalyst
Safari, Javad,Banitaba, Sayed Hossein,Khalili, Shiva Dehghan
experimental part, p. 1061 - 1069 (2012/07/03)
A green and convenient approach to the synthesis of 2-amino-4,6- diphenylnicotinonitriles via four-component reaction of malononitrile, aromatic aldehydes, acetophenone derivatives and ammonium acetate in water under ultrasound irradiation is described. The combinatorial synthesis was achieved for this methodology with applying ultrasound irradiation while making use of water as green solvent. In comparison to conventional methods, experimental simplicity, good functional group tolerance, excellent yields, short routine, and selectivity without the need for a transition metal or base catalyst are prominent features of this sonocatalyzed procedure.
Microwave assisted synthesis and antimicrobial activities of some 2-amino-4-aryl-3-cyano-6-(4'-hydroxy phenyl)-pyridines
Gothwal, Priya,Malhotra, Gunwanti,Srivastava
experimental part, p. 119 - 122 (2012/02/13)
4'-Hydroxy chalcones were treated with malononitrile in the presence of ammonium acetate under solventless microwave assisted condition to get 2-amino-4-aryl-3-cyano-6-(4'-hydroxy phenyl)-pyridines. The prepared compounds were screened for their antimicrobial activity; some of them have exhibited promising antimicrobial activity.
Malononitriles and Cyanoesters: Part VII- Diaryl- and Dithienylpropenones and -cyanopyridines and Their Molluscicidal Activity
Latif, N.,Asaad, F. M.,Girgis, N. S.
, p. 463 - 466 (2007/10/02)
2-Amino-3-cyano-4,6-disubstituted-pyridines (6) and 3-cyano-4,6-disubstituted-pyridin-2-ones (10) are obtained by reacting the corresponding propenones (1) with malononitrile and ethyl cyanoacetate, respectively, in the presence of ammonium acetate.The compounds (6) and (10) can be readily obtained by reacting the corresponding ylidene-malononitriles (8) and -cyanoesters (9) with the appropriate ketone.Molluscicidal activity of the compounds is also discussed.
