795290-06-1

Upstream product

• 74-88-4 methyl iodide 
• 994-30-9 triethylsilyl chloride 
• 945534-60-1 (2R,3R,4S,5S,6R,1'R,2'S,4'S)-2-{1'-(tert-butyl-dimethylsilyloxy)-2'-hydroxy-5'-benzyloxy-4'-methoxy-pentyl}-4-((R)-1-phenylethoxy)-6-allyl-2-hydroxy-3,5-dimethyl-2,3,5,6-tetrahydro-4H-pyran 
• 945534-59-8 (2S,4S,5R,7R,8S,9S,10E)-1-benzyloxy-5-[(tert-butyl)-dimethylsilyloxy]-2-methoxy-4-hydroxy-7,9-dimethyl-8-((1'R)-1'-phenylethoxy)dodec-10-en-6-one 
• 945534-58-7 (3R,4S,5S,6E)-1-[(tert-butyl)-dimethylsilyloxy]-3,5-dimethyl-4-((1'R)-1'-phenylethoxy)oct-6-en-2-one 
• 945534-62-3 (2R,3R,4S,5S,6R,1'R,2'S,4'S)-2-[1',2'-diacetoxy-5'-benzyloxy-4'-methoxy-pentyl]-4-triethylsilyloxy-6-allyl-2-methoxy-3,5-dimethyl-2,3,5,6-tetrahydro-4H-pyran 
• 945534-61-2 (2R,3R,4S,5R,6R,1'R,2'S,4'S)-2-[1',2'-diacetoxy-5'-benzyloxy-4'-methoxypentyl]-4-hydroxy-6-allyl-2-methoxy-3,5-dimethyl-2,3,5,6-tetrahydro-4H-pyran 

Downstream Products

• 795290-08-3 C₆₁H₁₁₂O₁₇Si₃ 
• 795290-07-2 C₆₁H₁₁₁IO₁₇Si₃ 

Relevant academic research and scientific papers

Short synthesis of the C16-C28 polyketide fragment of apoptolidin A aglycone

Starting from (E,E)-1-[(1R)-(phenylethyl)oxy]-2-methylpenta-1,3-diene and triethylsilyl enol ether of butanone rapid access to Koert's advanced C 10-C28 polyketide fragment of apoptolidin A is now possible. The Royal Society of Chemi

Total synthesis of apoptolidin

A ring-size-selective macrolactonization and the early introduction of the saccharide portions are the main features of a total synthesis of the 20-membered macrolide apoptolidin (see formula), which induces apoptosis in rat glia cells transformed with oncogenes.