795296-99-0Relevant academic research and scientific papers
Rational Design of Programmable Monodisperse Semi-Synthetic Protein Nanomaterials Containing Engineered Disulfide Functionality**
Bhandari, Pavankumar Janardhan,Sandanaraj, Britto S.
, p. 2966 - 2972 (2021/08/07)
The reversible nature of disulfide functionality has been exploited to design intelligent materials such as nanocapsules, micelles, vesicles, inorganic nanoparticles, peptide and nucleic acid nanodevices. Herein, we report a new chemical methodology for t
SUPRAMOLECULAR PROTEIN ASSEMBLIES WITH ADVANCED FUNCTIONS AND SYNTHESIS THEREOF
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Paragraph 0492-0493, (2019/05/18)
The present invention discloses stimuli-sensitive protein conjugate which can make supramolecular protein assemblies and methods for using the same. The present invention provides simple and rational process for construction of said stimuli-sensitive spherical protein assemblies through supramolecular chemical strategy.
GENERATION-DEPENDENT SUPRAMOLECULAR ASSEMBLIES OF PROTEIN-DENDRON CONJUGATES
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Page/Page column 22; 25-26, (2019/06/23)
The present invention discloses monodisperse protein-dendron conjugates that self-assemble to generation-dependent supramolecular protein assemblies of different size and surface charges. The invention further provides a process for synthesis of protein-dendron conjugates containing hydrophobic dendron of different generations.
Rational Design of Supramolecular Dynamic Protein Assemblies by Using a Micelle-Assisted Activity-Based Protein-Labeling Technology
Sandanaraj, Britto S.,Reddy, Mullapudi Mohan,Bhandari, Pavankumar Janardhan,Kumar, Sugam,Aswal, Vinod K.
supporting information, p. 16085 - 16096 (2018/10/15)
The self-assembly of proteins into higher-order superstructures is ubiquitous in biological systems. Genetic methods comprising both computational and rational design strategies are emerging as powerful methods for the design of synthetic protein complexes with high accuracy and fidelity. Although useful, most of the reported protein complexes lack a dynamic behavior, which may limit their potential applications. On the contrary, protein engineering by using chemical strategies offers excellent possibilities for the design of protein complexes with stimuli-responsive functions and adaptive behavior. However, designs based on chemical strategies are not accurate and therefore, yield polydisperse samples that are difficult to characterize. Here, we describe simple design principles for the construction of protein complexes through a supramolecular chemical strategy. A micelle-assisted activity-based protein-labeling technology has been developed to synthesize libraries of facially amphiphilic synthetic proteins, which self-assemble to form protein complexes through hydrophobic interaction. The proposed methodology is amenable for the synthesis of protein complex libraries with molecular weights and dimensions comparable to naturally occurring protein cages. The designed protein complexes display a rich structural diversity, oligomeric states, sizes, and surface charges that can be engineered through the macromolecular design. The broad utility of this method is demonstrated by the design of most sophisticated stimuli-responsive systems that can be programmed to assemble/disassemble in a reversible/irreversible fashion by using the pH or light as trigger.
HYDROPHOBIN MIMICS: PROCESS FOR PREPARATION THEREOF
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Paragraph 0124; 0125; 0206; 0207; 0208-0215, (2017/09/02)
The present invention discloses hydrophobin mimics of formula (I) comprising a protein head group, hydrophilic linker and hydrophobic tail and to a process for synthesis of library of hydrophobin mimics thereof. The hydrophobin mimics of the present invention self-assemble to form protein nanoparticles/nanocontainer either alone or in a specified chemical environment. The hydrophobin mimics (I) of the present invention find application in area of bio-nanotechnology.
Solution-phase assembly of a rhodium complex via specific hydrogen bonding between barbituric acid and triaminopyrimidine moieties
Kondo, Masataka,Kochi, Takuya,Sato, Mitsuo,Kitajima, Aki,Kakiuchi, Fumitoshi
supporting information; experimental part, p. 1166 - 1167 (2011/02/28)
Solution-phase assembly of a Rh complex using specific hydrogen bonding between BA and TAP moieties was achieved by tuning the substituent on TAP to control the solubility of the assembly.
Dendritic chiral phosphine lewis bases-catalyzed asymmetric aza-Morita-Baylis-Hillman reaction of N-sulfonated imines with activated olefins
Liu, Ying-Hao,Shi, Min
supporting information; experimental part, p. 122 - 128 (2009/04/10)
A series of polyether dendritic chiral phosphine Lewis bases was synthesized, and successfully applied to the asymmetric aza-Morita - Baylis - Hill -man reaction of N - sulfonated imines (N - arylmethyl -idene-4- methylbenzenesulfonamides) with methyl vin
Effect of guest molecule flexibility in access to dendritic interiors
Aathimanikandan, Sivakumar V.,Sandanaraj, Britto S.,Arges, Christopher G.,Bardeen, Christopher J.,Thayumanavan
, p. 2809 - 2812 (2007/10/03)
(Figure Presented) Dendrimers are attractive scaffolds for catalysis, since catalytic sites can be isolated and the catalysts are recoverable and reusable. Herein, we show that conformationally constrained molecules have better access to dendritic cores c
Probing every layer in dendrons
Sivanandan, Kulandaivelu,Aathimanikandan, Sivakumar V.,Arges, Christopher G.,Bardeen, Christopher J.,Thayumanavan
, p. 2020 - 2021 (2007/10/03)
Dendrons with a fluorescent probe in a specific location have been synthesized and characterized. Accessibility of guest molecules to each of these layers was then analyzed using an intermolecular photoinduced electron-transfer process. Comparisons of the
