79548-61-1

Basic information

• Product Name: triptonolide
• Synonyms: (3bR,9bS)-6-hydroxy-7-isopropyl-9b-Methyl-3b,4,10,11-tetrahydrophenanthro[2,1-c]furan-1,5(3H,9bH)-dione
• CAS NO: 79548-61-1
• Molecular Formula: C20H22O4
• Molecular Weight: 326.38628
• Mol File: 79548-61-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 555.7°C at 760 mmHg
• Flash Point: 201.6°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 5.91E-13mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: triptonolide(CAS DataBase Reference)
• NIST Chemistry Reference: triptonolide(79548-61-1)
• EPA Substance Registry System: triptonolide(79548-61-1)

Safety Data

• Hazardous Substances Data: 79548-61-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H22O4/c1-10(2)11-4-5-14-17(18(11)22)16(21)8-15-13-9-24-19(23)12(13)6-7-20(14,15)3/h4-5,10,15,22H,6-9H2,1-3H3/t15-,20+/m1/s1

Upstream product

• 1408320-09-1 (S)-6-hydroxy-7-isopropyl-9b-methyl-10,11-dihydrophenanthro[1,2-c]furan-1,5(3H,9bH)-dione 
• 1423022-34-7 (4aS,10aS)-ethyl 8-methoxy-4a-methyl-2-oxo-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate 
• 1423022-35-8 (4aS,10aR)-ethyl 8-methoxy-4a-methyl-2-(((trifluoromethyl)sulfonyl)oxy)-3,4,4a,9,10,10a-hexahydrophenanthrene-1-carboxylate 
• 1423022-17-6 (4aS,10aR)-1-(hydroxymethyl)-8-methoxy-4a-methyl-3,4,4a,9,10,10a-hexahydrophenanthren-2-yl trifluoromethanesulfonate 
• 38996-01-9 ethyl 3-hydroxypent-4-enoate 
• 120303-35-7 C₂₀H₂₃NO 
• 22418-80-0 3-oxopent-4-enoic acid ethyl ester 
• 1423022-32-5 C₂₅H₃₆O₄Si 
• 42263-75-2 1-methyl-5-methoxy-2-tetralone 
• 1209485-40-4 (3bR,9bS)-6-methoxy-9b-methyl-3b,4,5,9b,10,11-hexahydrophenanthro[1,2-c]furan-1(3H)-one 
• 1209485-41-5 (3bR,9bS)-6-methoxy-9b-methyl-3b,4,10,11-tetrahydrophenanthro[1,2-c]furan-1,5(3H,9bH)-dione 
• 1209485-42-6 (3bR,9bS)-6-hydroxy-9b-methyl-3b,4,10,11-tetrahydrophenanthro[1,2-c]furan-1,5(3H,9bH)-dione 
• 67-63-0 isopropyl alcohol 
• 1408320-07-9 (S)-6-methoxy-9b-methyl-10,11-dihydrophenanthro[1,2-c]furan-1,5(3H,9bH)-dione 

Downstream Products

• 38647-11-9 l-triptonide 
• 38748-32-2 triptolide 

Relevant articles and documents

Metal-mediate reactions based formal synthesis of triptonide and triptolide

A formal synthesis of triptolide and triptonide has been achieved based on metal-mediate reactions. Specially, Noyori's ruthenium catalyzed enantioselective transfer hydrogenation, indium(III) catalyzed cationic polyene cyclization, palladium catalyzed ca

POLYCYCLIC EPOXIDES AND COMPOSITIONS THEREOF WITH ANTI-CANCER ACTIVITIES

The present technology provides polycyclic epoxides of Formula I, compositions comprising such expoxides and methods of using such epoxides. In particular, these compounds are useful for inhibiting cancer cell proliferation and tumor angiogenesis or treating ovarian, breast, prostate, liver, pancreatic, and colon cancers, as well as leukemia.

Efficient syntheis of the key intermediate triptophenolide methyl ether for the synthesis of(-)-triptolide

An efficient synthesis of triptophenolide methyl ether 4 from the readily available abietic acid 3 in nine steps is described and successfully applied to the synthesis of (-)-triptolide 1.The route is of characteristic of low cost, high yield and easy operation.In addition, every reaction in this route has been successfully scaled-up to a 100 g substrate level without loss of yield.