194608-87-2

Upstream product

• 194608-84-9 methyl 3-chloro-4-(3-(2-propyl-3-hydroxy-4-propionylphenoxy)propylthio)phenylacetate 
• 194792-52-4 methyl 3-chloro-4-(3-bromopropylthio)-phenylacetate 
• 91361-78-3 3-chloro-4-dimethylcarbamoylthio-phenylacetic acid methyl ester 
• 91373-91-0 (3-chloro-4-dimethylthiocarbamoyloxyphenyl)acetic acid methyl ester 
• 74815-88-6 2,4-dihydroxy-3-allylpropiophenone 
• 79558-49-9 2,4-dihydroxy-3-propylphenyl ethyl ketone 
• 57017-95-5 methyl 3-chloro-4-hydroxyphenylacetate 
• 5792-36-9 2',4'-dihydroxypropiophenone 
• 194608-85-0 {3-Chloro-4-[3-(3-hydroxy-4-{1-[(E)-hydroxyimino]-propyl}-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester 

Relevant academic research and scientific papers

Phenylacetic acid derivatives as hPPAR agonists

Beginning with the weakly active lead structure 1, a new series of hPPAR agonists was developed. In vivo glucose and triglyceride lowering activity was obtained by homologation and oxamination to 3, then conversion to substituted benzisoxazoles 4 and 5. F