79592-92-0

Usage

Uses

Used in Pharmaceutical Industry:
23-O-DesMycinosyl-tylosin is used as an orally effective antibiotic for treating bacterial infections. Its modification at the aldehyde functional group allows for improved pharmacokinetics and enhanced efficacy against a range of bacterial pathogens.
Additionally, 23-O-DesMycinosyl-tylosin serves as a degradation product of tylosin macromolecules, which can be further studied and utilized in the development of new antibiotics or understanding the degradation mechanisms of macrolide antibiotics.

InChI:InChI=1/C38H63NO13/c1-10-29-26(19-41)15-20(2)11-12-27(42)21(3)16-25(13-14-40)34(22(4)28(43)17-30(44)50-29)52-37-33(45)32(39(8)9)35(23(5)49-37)51-31-18-38(7,47)36(46)24(6)48-31/h11-12,14-15,21-26,28-29,31-37,41,43,45-47H,10,13,16-19H2,1-9H3/b12-11+,20-15+/t21-,22+,23-,24+,25+,26-,28-,29-,31+,32-,33-,34-,35+,36+,37+,38-/m1/s1

Upstream product

• 90232-56-7 4-'''-O-(dimethyl-t-butylsilyl)tylosin 
• 90232-69-2 2'.4'',20-tri-O-acetyltylosin-3,20-hemiacetal 
• 90232-68-1 2',4'',20-tri-O-acetyl-4'''-O-(dimethyl-t-butylsilyl)tylosin 3,20-hemiacetal 
• 18423-82-0 L-mycarose 
• 81114-52-5 (7E,9E)-(3aR,5R,11R,12R,16R,17S,17aS)-12-Ethyl-16-hydroxy-2-methoxy-5,9,17-trimethyl-11-trityloxymethyl-3,3a,4,5,11,12,15,16,17,17a-decahydro-2H-1,13-dioxa-cyclopentacyclohexadecene-6,14-dione 
• 84120-89-8 C₆₃H₈₄BrNO₁₆ 
• 84120-94-5 (7E,9E)-(3aR,5R,11R,12R,16R,17S,17aS)-12-Ethyl-2,16-dihydroxy-5,9,17-trimethyl-11-trityloxymethyl-3,3a,4,5,11,12,15,16,17,17a-decahydro-2H-1,13-dioxa-cyclopentacyclohexadecene-6,14-dione 
• 51548-96-0 1-α-bromo-2,4-diacetyl-mycaminose hydrobromide 
• 84171-64-2 4-O-acetyl-1,5-anhydro-2,6-dideoxy-3-C-methyl-L-ribo-hex-1-enitol 
• 3067-23-0 4-O-acetylmycarose 
• 1401-69-0 tylosin 
• 121530-10-7 2',4'',20-tri-O-acetyl-2''',3'''-didehydro-2'''-demethoxy-4'''-deoxy-4'''-oxotylosin 3,20-hemiacetal 
• 84134-59-8 C₄₂H₆₇NO₁₅ 
• 84134-58-7 C₅₄H₇₁NO₁₂ 

Downstream Products

• 81307-38-2 23-O-demycinosyl-23-O-phenylacetyltylosin 
• 121512-74-1 23-O-benzoyl-23-O-demycinosyltylosin 
• 121512-73-0 2'-O-acetyl-23-O-benzoyl-23-O-demycinosyltylosin 
• 132059-76-8 C₄₉H₇₅N₃O₁₅S 
• 132059-77-9 C₅₀H₇₇N₃O₁₅S 
• 873783-00-7 C₄₆H₇₀N₂O₁₄ 

Relevant academic research and scientific papers

Semisynthetic Macrolide Antibacterials Derived from Tylosin. Synthesis of 23-O-Demycinosyltylosin and Related Compounds

The synthesis of a versatile intermediate 4'''-O-(dimethyl-t-butylsilyl)tylosin, directly from tylosin, is described.Its utility in the synthesis of selected acyl derivatives of tylosin, as well in the synthesis of 23-O-demycinosyltylosin, is discussed.Li

TOTAL SYNTHESIS OF TYLOSIN

Tylosin has been synthesized by regio- and stereoselective introduction of the amino disaccharide moiety and D-mycinose onto the previously synthesized 16-membered-ring aglycone.