79606-49-8Relevant academic research and scientific papers
A simple copper-catalyzed synthesis of tertiary acyclic amides
Racine, Emilie,Monnier, Florian,Vors, Jean-Pierre,Taillefer, Marc
, p. 2818 - 2821 (2011/07/09)
The N-arylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper catalytic system. The corresponding tertiary acyclic amides, which can be found in numerous biologically active compounds, have been obtained in good to excellent yields.
Convenient synthesis of triarylamines via ester-mediated nucleophilic aromatic substitution
Hattori, Tetsutaro,Satoh, Takashi,Miyano, Sotaro
, p. 514 - 518 (2007/10/03)
A convenient method for the preparation of arylamines via nucleophilic displacement of methoxy- and/or fluorobenzoates with lithium amides is presented. Treatment of 2,6-di-tert-butyl-4-methoxyphenyl 2- or 4-fluorobenzoate (2 or 7) with lithium diarylamid
Promotion of reaction of N-H bonds with triarylbismuth and cupric acetate
Chan, Dominic M. T.
, p. 9013 - 9016 (2007/10/03)
Arylation of a diverse group of N-H containing compounds at room temperature with triarylbismuth and cupric acetate in the presence of a tertiary amine promoter, such as triethylamine or pyridine, is described. This mild and highly efficient procedure, which is based on Barton's earlier work on the arylation of amines, can be applied to amides, imides, ureas, carbamates, and sulfonamides. Copyright (C) 1996 Elsevier Science Ltd.
p-Fluorobenzoyl Chloride for Characterization of Active Hydrogen Functional Groups by Fluorine-19 Nuclear Magnetic Resonance Spectrometry
Spratt, M. P.,Dorn, H. C.
, p. 2038 - 2043 (2007/10/02)
The base-catalyzed reactions of p-fluorobenzoyl chloride provide a convenient method for (19)F NMR analysis of alcohols, phenols, carboxylic acids, amines, and thiols.The (19)F chemical shift and yield data for p-fluorobenzoyl derivatives for nearly 100 compounds are presented.The yield data for these p-fluorobenzoyl derivatives suggest a simple, and in many cases, quantitative method for introducing a fluorine tagging group.The (19)F chemical shifts indicate a wide chemical shift range (ca. 10 ppm) for a large number of compounds.Furthermore, most chemical classes (e.g., phenols, alcohols, etc.) have fairly well resolved chemical shift regions.
