A novel, mild, and facile method to prepare 6-methylidene pe nem derivatives

DOI: 10.1021/jo049880g

Source and publish data:

Journal of Organic Chemistry p. 5850 - 5860 (2004)

Update date:2022-08-04

Topics: Facile Method Mild

Authors:

Abe, Takao

Sato, Chisato

Ushirogochi, Hideki

Sato, Koichi

Takasaki, Tsuyoshi

Isoda, Takeshi

Mihira, Ado

Yamamura, Itsuki

Hayashi, Kazuhiko

Kumagai, Toshio

Tamai, Satoshi

Shiro, Motoo

Venkatesan, Aranapakam M.

Mansour, Tarek S.

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Article abstract of DOI:10.1021/jo049880g

A novel and mild method was established to synthesize 6-methylidene penem compounds. This method entails a MgBr₂/Et₃N-promoted aldol-type condensation on 6-bromopenem 12 with an appropriately substituted aldehyde to yield the interme

Full text of DOI:10.1021/jo049880g

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