79660-72-3 Usage
Description
Fleroxacin is a new, once daily trifluoroquinolone antibacterial structurally related to
norfloxacin. Available in both oral and IV formulations, it is reportedly useful in the
treatment of gonorrhea, bacterial enteritis, chronic bronchitis and urinary tract
infections. Fleroxacin has a longer serum half-life (9-12 hours) than other drugs of this
class, such as ciprofloxacin, enoxacin and norfloxacin.
Uses
antibiotic
Definition
ChEBI: A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-n
gative bacteria.
Manufacturing Process
6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-
oxoquinoline-3-carboxylic acid hydrochloride:A mixed solution of 1-methylpiperazine (0.34 g) and pyridine (3 ml) was
added to 6,7,8-trifluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxoquinoline-3-
carboxylic acid (0.12 g) and heated to reflux for 6 hours. After the solvent
evaporated and cooled, the residue was adjusted to pH 1 with aqueous
hydrochloric acid. The cooled mixture was filtered off and the solid
recrystallized from water to give 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-
(4-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (0.08
g), melting point 269-271°C (decomp.).
Brand name
Quinodis
Therapeutic Function
Antibacterial
Check Digit Verification of cas no
The CAS Registry Mumber 79660-72-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,6,6 and 0 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 79660-72:
(7*7)+(6*9)+(5*6)+(4*6)+(3*0)+(2*7)+(1*2)=173
173 % 10 = 3
So 79660-72-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)
79660-72-3Relevant articles and documents
NOVEL METHOD OF SYNTHESIS OF FLUOROQUINOLONES
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Page/Page column 6; 8-9, (2009/04/24)
The invention relates to a method of preparation of fluoroquinolones of formula (I) from compounds of formula (II): in which R1, R2, R3, R4, R5, R6, R7, and X are as defined in Claim 1.
A process for the preparation of quinoline carboxylic acid derivatives
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, (2008/06/13)
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Quinoline carboxylic acid derivatives and process for the preparation
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, (2008/06/13)
This invention relates to new compounds of value as antibacterial agent. More particularly, it relates to quinoline carboxylic acid derivatives, the hydrates and the salts thereof.
