79660-72-3 Hazards Identification
Pictogram(s):
Signal:
Warning
GHS Hazard Statements:
H371 (100%): May cause damage to organs [Warning Specific target organ toxicity, single exposure]
Precautionary Statement Codes:
P260, P264, P270, P308+P316, P405, and P501
Hazard Classes and Categories:
STOT SE 2 (100%)
79660-72-3 Usage
Uses
Used in Antibacterial Applications:
Fleroxacin is used as an antibiotic for the treatment of various bacterial infections, including gonorrhea, bacterial enteritis, chronic bronchitis, and urinary tract infections. Its longer serum half-life allows for once-daily dosing, making it a convenient option for patients.
Used in Pharmaceutical Industry:
Fleroxacin is used as a broad-spectrum antibiotic in the pharmaceutical industry for the development of medications to combat a wide range of bacterial infections. Its unique structural properties and extended half-life make it a valuable asset in the fight against antibiotic-resistant bacteria.
Manufacturing Process
6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-
oxoquinoline-3-carboxylic acid hydrochloride:A mixed solution of 1-methylpiperazine (0.34 g) and pyridine (3 ml) was
added to 6,7,8-trifluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxoquinoline-3-
carboxylic acid (0.12 g) and heated to reflux for 6 hours. After the solvent
evaporated and cooled, the residue was adjusted to pH 1 with aqueous
hydrochloric acid. The cooled mixture was filtered off and the solid
recrystallized from water to give 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-
(4-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (0.08
g), melting point 269-271°C (decomp.).
Therapeutic Function
Antibacterial
Check Digit Verification of cas no
The CAS Registry Mumber 79660-72-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,6,6 and 0 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 79660-72:
(7*7)+(6*9)+(5*6)+(4*6)+(3*0)+(2*7)+(1*2)=173
173 % 10 = 3
So 79660-72-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)
79660-72-3Relevant academic research and scientific papers
NOVEL METHOD OF SYNTHESIS OF FLUOROQUINOLONES
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Page/Page column 6; 8-9, (2009/04/24)
The invention relates to a method of preparation of fluoroquinolones of formula (I) from compounds of formula (II): in which R1, R2, R3, R4, R5, R6, R7, and X are as defined in Claim 1.
Process for making antimicrobial compounds
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, (2008/06/13)
The present invention provides a process for making a compound having a structure according to Formula (I) STR1 wherein A1, A2 and A3 are independently carbon or nitrogen and R1, R3, R4 and R6 are known quinolone substituents; and wherein one of R1, R3 or R6 may be a lactam-containing moiety; or a protected form, salt, pharmaceutically-acceptable salt, biohydrolyzable ester, or solvate thereof; the process comprising reacting one or more organosilicon compounds with a compound having a structure according to Formula (II) STR2 wherein A1, A2 and A3, R1, R3, R4 and R6 as described above; wherein one of R1, R3 or R6 may be a lactam-containing moiety; and X is a leaving group; or a protected form, salt, biohydrolyzable ester, or solvate thereof. The compounds prepared according to the processes of the invention are themselves useful as antimicrobials, or they may be used as intermediates for making other quinolone-containing antimicrobials.
Qunoline intermediates useful therein for synthesizing antibacterial compounds
-
, (2008/06/13)
A novel process and intermediates used therein for linking a cephalosporin compound to a quinolone are disclosed. According to the disclosed process, the 2-carboxylic acid moiety of the cephalosporin compound is treated with an organic base. The resulting salt is then reacted with a quinolone compound which has been activated using a haloformate. The reaction is run in a non-aqueous organic solvent. 4-Dimethylaminopyridine is used to promote the reaction between the cephalosporin salt and the activated quinolone.
Quinoline carboxylic acid derivatives and process for the preparation
-
, (2008/06/13)
This invention relates to new compounds of value as antibacterial agent. More particularly, it relates to quinoline carboxylic acid derivatives, the hydrates and the salts thereof.
