82419-46-3

Usage

InChI:InChI=1/C17H18FN3O4/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)25-7-6-21(13)9-11(15(10)22)17(23)24/h8-9H,2-7H2,1H3,(H,23,24)

Upstream product

• 82419-27-0 2-(2-bromoethoxy)-3,4-difluoronitrobenzene 
• 79660-72-3 fleroxacin 
• 82419-30-5 ethyl 9,10-difluoro-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzoxazine-6-carboxylate 
• 82419-28-1 2-(2-bromoethoxy)-3,4-difluoroaniline 
• 82419-29-2 7,8-difluoro-2,3-dihydro-4H-1,4-benzoxazine 
• 82419-26-9 2,3-difluoro-6-nitrophenol 
• 771-69-7 2,3,4-trifluoronitrobenzene 
• 109-01-3 1-methyl-piperazine 
• 82419-31-6 9,10-difluoro-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzoxazine-6-carboxylic acid 

Relevant academic research and scientific papers

Inter-and intramolecular photochemical reactions of fleroxacin

In the cation formed by photoinduced C-F bond cleavage in fleroxacin, intramolecular reaction with the W-ethyl chain is prevented by the electron-withdrawing effect of fluorine and intermolecular attack by nucleophiles is facilitated.2009 American Chemica

Synthesis and antibacterial activities of substituted 7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids

As part of a search for new synthetic antibacterial agents to combat systemic infection, various analogues of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids were synthesized. Among the compounds newly synthesized, 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[ 1,2,3-de][1,4]benzoxazine-6-carboxylic acid (DL-8280) showed potent antibacterial activity against Gram-positive and -negative pathogens, including Psedomonas aeruginosa, and its metabolic disposition was shown in separate experimentals to be favorable.