79685-41-9

Basic information

• Product Name: 5-chloro-2-methanesulfonylpyrimidine-4-carboxylic acid methyl ester
• Synonyms: 5-chloro-2-methanesulfonylpyrimidine-4-carboxylic acid methyl ester
• CAS NO: 79685-41-9
• Molecular Weight: 250.663
• Mol File: 79685-41-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-chloro-2-methanesulfonylpyrimidine-4-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-methanesulfonylpyrimidine-4-carboxylic acid methyl ester(79685-41-9)
• EPA Substance Registry System: 5-chloro-2-methanesulfonylpyrimidine-4-carboxylic acid methyl ester(79685-41-9)

Safety Data

• Hazardous Substances Data: 79685-41-9(Hazardous Substances Data)

Upstream product

• 61727-33-1 5-chloro-2-(methylthio)pyrimidine-4-carboxylic acid 
• 79686-03-6 methyl 5-chloro-2-(methylsulfanyl)pyrimidine-4-carboxylate 

Downstream Products

• 943123-08-8 5-chloro-2-phenylaminopyrimidine-4-carboxylic acid methyl ester 

Relevant articles and documents

METHODS OF CHEMOTYPE EVOLUTION

Herein is described a method to rapidly screen a large chemical space for a compound that binds to a target protein through an iterative fragment assembly approach that can be performed at low reagent cost and without requiring purification of the assembled product. The method employs a library of test ligands each of which comprise a ‘bait’ molecule, which is known from prior art or prior screening to have some intrinsic affinity for the target protein, and a test moiety.

Pyrimidine-2-sulphides and their S-oxides for use in medicine and methods of use therefor, pharmaceutical compositions containing them, processes for their preparation and per se novel sulphides and S-oxides

Compounds of the formula STR1 (wherein X represents a halogen atom; n is 0, 1 or 2; R1 and R2, which may be the same or different, each represents a hydrogen atom or a carboxyl, esterified carboxyl, amido or mono- or di-C1-4 alkylamido group or a C1-4 alkyl group which may if desired carry a carboxyl or esterified carboxyl group; and R3 represents a C1-32 saturated or unsaturated, straight or branched, cyclic or acyclic aliphatic group or an araliphatic or heterocyclic substituted aliphatic group, a heterocyclic group or an aryl group which groups may if desired carry one or more substituents selected from halogen atoms and oxo, nitro, hydroxy, etherified hydroxy, esterified hydroxy, primary, secondary or tertiary amino, acylamino etherified mercapto or S=O or --SO2 derivatives thereof and esterified phosphonic acid groups) and, where an acidic or basic group is present, physiologically compatible salts thereof have been found to be of use in combating abnormal cell proliferation. The compounds are prepared inter alia by oxidation of the corresponding sulfide, displacement of a leaving atom or group from the 2-position of the pyrimidine by reaction with a sulfinic acid or by ring closure of the pyrimidine ring.