79686-03-6

Basic information

• Product Name: 4-PyriMidinecarboxylic acid, 5-chloro-2-(Methylthio)-, Methyl ester
• Synonyms: 4-PyriMidinecarboxylic acid, 5-chloro-2-(Methylthio)-, Methyl ester;Methyl 5-chloro-2-(Methylthio)pyriMidine-4-carboxylate;5-Chloro-2-(methylthio)-4-pyrimidinecarboxylic Acid Methyl Ester
• CAS NO: 79686-03-6
• Molecular Formula: C₇H₇ClN₂O₂S
• Molecular Weight: 218.66068
• Mol File: 79686-03-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-PyriMidinecarboxylic acid, 5-chloro-2-(Methylthio)-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PyriMidinecarboxylic acid, 5-chloro-2-(Methylthio)-, Methyl ester(79686-03-6)
• EPA Substance Registry System: 4-PyriMidinecarboxylic acid, 5-chloro-2-(Methylthio)-, Methyl ester(79686-03-6)

Safety Data

• Hazardous Substances Data: 79686-03-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 79686-03-6 differently. You can refer to the following data:
1. 5-Chloro-2-(methylthio)-4-pyrimidinecarboxylic Acid Methyl Ester is a synthetic intermediate in the preparation of GSK3β inhibitors and non-nucleoside reverse transcriptase inhibitors for treating H IV infection.
2. 5-Chloro-2-(methylthio)-4-pyrimidinecarboxylic Acid Methyl Ester is a synthetic intermediate in the preparation of GSK3β inhibitors and non-nucleoside reverse transcriptase inhibitors for treating HIV infection.

Upstream product

• 61727-33-1 5-chloro-2-(methylthio)pyrimidine-4-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 

Downstream Products

• 1462949-87-6 methyl 2-(methylsulfonyl)-7-phenylthieno[3,2-d]pyrimidine-6-carboxylate 
• 1462949-88-7 methyl 2-(methylsulfanyl)-7-phenylthieno[3,2-d]pyrimidine-6-carboxylate 
• 1462947-64-3 7-(4-fluorophenyl)-2-{[4-(4-methylpiperazin-1-yl)-2-(propan-2-yloxy)phenyl]-amino}thieno[3,2-d]pyrimidine-6-carboxamide 
• 1462949-99-0 methyl 7-(4-fluorophenyl)-2-(methylsulfanyl)thieno[3,2-d]pyrimidine-6-carboxylate 
• 1462950-00-0 7-(4-fluorophenyl)-2-(methylsulfanyl)thieno[3,2-d]pyrimidine-6-carboxamide 
• 1462949-98-9 7-(4-fluorophenyl)-2-(methylsulfonyl)thieno[3,2-d]pyrimidine-6-carboxamide 
• 79685-41-9 5-chloro-2-methanesulfonylpyrimidine-4-carboxylic acid methyl ester 

Relevant articles and documents

AMINOPYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS

The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula: (I) where A, B, R1, X1, X2, and W are described herein.

METHODS OF CHEMOTYPE EVOLUTION

Herein is described a method to rapidly screen a large chemical space for a compound that binds to a target protein through an iterative fragment assembly approach that can be performed at low reagent cost and without requiring purification of the assembled product. The method employs a library of test ligands each of which comprise a ‘bait’ molecule, which is known from prior art or prior screening to have some intrinsic affinity for the target protein, and a test moiety.

NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF

The present invention relates to compounds of formula (I): wherein R6 is -CONH2 or a -C(Rα)(Rβ)(OH) group; R is a substituted phenyl or heteroaryl group; R7 is an optionally substituted aryl or heteroaryl group. Process for the preparation thereof and therapeutic use thereof.