796874-25-4Relevant academic research and scientific papers
Development of Transition-Metal-Free Lewis Acid-Initiated Double Arylation of Aldehyde: A Facile Approach Towards the Total Synthesis of Anti-Breast-Cancer Agent
Kumar Hazra, Chinmoy,Mahato, Rina,Sharma, Pragya,Singh, Sanjay,Vodnala, Nagaraju,Yadav, Naveen
, (2022/02/19)
This work describes a mild and robust double hydroarylation strategy for the synthesis of symmetrical /unsymmetrical diaryl- and triarylmethanes in excellent yields using Lambert salt (0.2–1.0 mol%). Despite the anticipated challenges associated with controlling selective product formation, unsymmetrical diaryl- and triarylmethanes products are obtained unprecedentedly. A highly efficient gram scale reaction has also been reported (TON for symmetrical product=475 and for unsymmetrical product=390). The synthetic utility of the methodology is demonstrated by the preparation of several unexplored diaryl- and triarylmethane-based biologically relevant molecules, such as arundine, vibrindole A, turbomycin B, and certain anti-inflammatory agents. A total synthesis of an anti-breast-cancer agent is also demonstrated. Control experiments, Hammett analysis, HRMS and GC-MS studies reveal the reaction intermediates and reaction mechanism.
Diaryloxy methano phenanthrenes: A new class of antituberculosis agents
Panda, Gautam,Shagufta,Mishra, Jitendra Kumar,Chaturvedi, Vinita,Srivastava, Anil K.,Srivastava, Ranjana,Srivastava, Brahm S.
, p. 5269 - 5276 (2007/10/03)
A new series of diaryloxy methano phenanthrenes were prepared through tertiary-aminoalkylations of [(methoxy-phenyl)-phenanthren-9-yl-methyl]-phenols obtained from Friedel-Crafts alkylations on (methoxy-phenyl)-phenanthren-9-yl- methanols. These series of
