4707-71-5Relevant articles and documents
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Hewett
, p. 193,195 (1938)
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Bifunctional antitumor agents. Derivatives of pyrrolo[9,10-b]phenanthrene - A DNA intercalative delivery template
Jones, Graham B.,Mathews, Jude E.
, p. 14599 - 14614 (1997)
The preparation and intercalative ability of the pyrrolo[9,10-b]phenanthrene nucleus is described. Functionalization of the nucleus was achieved using standard indole chemistry. The utility of this template as a DNA intercalating drug delivery system is demonstrated by synthesis of a derived bis-chloroethylamine alkylating system and a hybrid DNA interactive enediyne system.
Microwave-assisted Vilsmeier-Haack formylation of aromatic substrates
Ghosh, Kumaresh,Adhikari, Suman
experimental part, p. 959 - 961 (2009/12/24)
A microwave-assisted Vilsmeier-Haack formylation reaction has been studied on various amines, phenols and polynuclear hydrocarbons under solvent free condition that rapidly affords higher yield of products compared to traditional thermal condition.
Therapeutics for chemokine mediated diseases
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, (2008/06/13)
The invention provides therapeutic and biological uses of chemokine-receptor-binding compounds (including chemokine receptor ligands such as chemokine receptor agonists or antagonists), such as tricyclic phenanthrene derivatives, including uses in the treatment of disease states mediated by chemokines. The relevant chemokines may for example be monocyte chemoattractant protein-one (MCP-1) or interleukin-8 (IL-8), and the relevant chemokine receptors may for example be corresponding chemokine receptors (CCR-2, CCR-4, CXCR-1, and CXCR-2). In other aspects, the invention provides corresponding pharamaceutical compositions and therapeutic methods. In one aspect, for example, the invention provides for the use of phenanthrene-9,10-dione in the treatment of multiple sclerosis.