796964-13-1

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General Description

1-Methyl-2-phenyl-3-propylindole, also known as 3-Methyl-2-phenylindole, is a chemical compound with the molecular formula C17H17N. It is a derivative of the indole class of compounds, which are commonly found in various natural products and pharmaceuticals. This particular chemical is known for its potential use in medicinal and research applications, particularly in the development of drugs targeting the central nervous system. Its structure and properties make it a promising candidate for studying the interaction of indole derivatives with biological receptors, as well as for the development of new therapeutic agents for various neurological disorders and conditions. Despite its potential, 1-Methyl-2-phenyl-3-propylindole is also a controlled substance due to its psychoactive properties, and it is important to use and handle it with caution in a controlled laboratory setting.

Upstream product

• 4250-81-1 1-phenyl-1-pentyne 
• 932-32-1 N-methyl-2-chloroaniline 
• 869301-70-2 [2-((Z)-1-Benzenesulfonyl-2-phenyl-vinyl)-phenyl]-methyl-amine 
• 107-08-4 1-iodo-propane 
• 29055-08-1 N-methyl-o-aminobenzyl alcohol 
• 103-67-3 benzyl-methyl-amine 
• 1020957-75-8 2-((benzyl)methylamino)benzaldehyde 
• 618-40-6 1-Methyl-1-phenylhydrazine 
• 614-00-6 N-methyl-N-nitrosoaniline 
• 1486473-69-1 N-benzyl-2-(buta-1,3-dien-1-yl)-N-methylaniline 
• 446-52-6 2-Fluorobenzaldehyde 
• 85-91-6 Methyl N-methylanthranilate 
• 240493-91-8 (2-bromomethyl-phenyl)-methyl-carbamic acid tert-butyl ester 
• 240493-90-7 tert-butyl (2-(hydroxymethyl)phenyl)(methyl)carbamate 

Relevant academic research and scientific papers

Co(III)-Catalyzed, Internal and Terminal Alkyne-Compatible Synthesis of Indoles

A Co(III)-catalyzed, internal and terminal alkyne-compatible indole synthesis protocol is reported herein. The N-amino (hydrazine) group imparts distinct, diverse reactivity patterns for directed C-H functionalization/cyclization reactions. Notable synthetic features include regioselectivity for a meta-substituted arylhydrazine, regioselectivity for a chain-branched terminal alkyne, formal incorporation of an acetylenic unit through C2-desilylation on a C2-silylated indole derivative, formal inversion of regioselectivity through consecutive C3-derivatization and C2-desilylation processes, and formal bond migration for a linear-chain terminal alkyne.

Ruthenium(II)-Catalyzed Traceless C?H Functionalization Using an N?N Bond as an Internal Oxidant

A previously elusive RuII-catalyzed N?N bond-based traceless C?H functionalization strategy is reported. An N-amino (i.e., hydrazine) group is used for the directed C?H functionalization with either an alkyne or an alkene, affording an indole derivative or olefination product. The synthesis features a broad substrate scope, superior atom and step economy, as well as mild reaction conditions.

A Versatile, Traceless C-H Activation-Based Approach for the Synthesis of Heterocycles

A versatile, traceless C-H activation-based approach for the synthesis of diversified heterocycles is reported. Rh(III)-catalyzed, N-amino-directed C-H alkenylation generates either olefination products or indoles (in situ annulation) in an atom- and step-economic manner at room temperature. The remarkable reactivity endowed by this directing group enables scale-up of the reaction to a 10 g scale at a very low catalyst loading (0.01 mol %/0.1 mol %). Ex situ annulation of olefination product provides entry into an array of heterocycles.

Efficient cyclization of tertiary amines and alkenes promoted by KOt-Bu-DMF

Nitrogen heterocycles could be prepared in good yields via intramolecular cyclization of tertiary amines and alkenes promoted by KOt-Bu-DMF. This journal is The Royal Society of Chemistry 2013.

Novel synthesis of 2-aryl and 2,3-disubstituted indoles by modified double elimination protocol

(Chemical Equation Presented) Syntheses of 2-aryl and 2,3-substituted indoles were realized by modified double elimination protocol. Under basic conditions, vinyl sulfones derived from the reaction of 2-aminobenzyl sulfone with benzaldehydes underwent cyclization and alkylation followed by elimination of sulfinic acid to afford 2,3-substituted indoles.

The first regioselective palladium-catalyzed indolization of 2-bromo- or 2-chloroanilines with internal alkynes: A new approach to 2,3-disubstituted indoles

(Chemical Equation Presented) The first practical and economical process for synthesis of 2,3-disubstituted indole compounds has been developed with high regioselectivity by palladium-catalyzed indolization of 2-bromo- or chloroanilines and their derivatives with internal alkynes.