797036-07-8Relevant academic research and scientific papers
Synthesis and biological evaluation of triazolothienopyrimidine derivatives as novel HIV-1 replication inhibitors
Kim, Junwon,Kwon, Jeongjin,Lee, Doohyun,Jo, Suyeon,Park, Dong-Sik,Choi, Jihyun,Park, Eunjung,Hwang, Jong Yeon,Ko, Yoonae,Choi, Inhee,Ju, Moon Kyeong,Ahn, Jiye,Kim, Junghwan,Han, Sung-Jun,Kim, Tae-Hee,Cechetto, Jonathan,Nam, Jiyoun,Ahn, Sujin,Sommer, Peter,Liuzzi, Michel,No, Zaesung,Lee, Jinhwa
, p. 153 - 157 (2013)
We identified a novel class of triazolothienopyrimidine (TTPM) compounds as potent HIV-1 replication inhibitors during a high-throughput screening campaign that evaluated more than 200,000 compounds using a cell-based full replication assay. Herein, we report the optimization of the antiviral activity in a cell-based assay system leading to the discovery of aryl-substituted TTPM derivatives (38, 44, and 45), which exhibited significant inhibition of HIV-1 replication with acceptable safety margins. These novel and potent TTPMs could serve as leads for further development.
