797036-27-2

Basic information

• Product Name: 2-((3-methoxyphenyl)sulfonyl)acetonitrile
• Synonyms: 2-((3-methoxyphenyl)sulfonyl)acetonitrile
• CAS NO: 797036-27-2
• Molecular Weight: 211.241
• Mol File: 797036-27-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-((3-methoxyphenyl)sulfonyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((3-methoxyphenyl)sulfonyl)acetonitrile(797036-27-2)
• EPA Substance Registry System: 2-((3-methoxyphenyl)sulfonyl)acetonitrile(797036-27-2)

Safety Data

• Hazardous Substances Data: 797036-27-2(Hazardous Substances Data)

Upstream product

• 15570-12-4 3-methoxybenzenethiol 
• 79506-65-3 (3-methoxyphenylsulfanyl)acetonitrile 
• 766-85-8 3-methoxy-1-iodobenzene 
• 1624363-23-0 3-azido-2-methylbut-3-en-2-ol 
• 10130-74-2 m-Methoxybenzenesulfonyl chloride 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 1260149-75-4 2-[(3-methoxyphenyl)sulfonyl]-1-phenylethan-1-one 
• 1416903-55-3 C₁₄H₁₀N₄O₄S₂ 
• 1416903-26-8 C₁₈H₁₇N₅O₄S₂ 
• 1416903-63-3 C₁₄H₉ClN₄O₃S₂ 

Relevant articles and documents

Photoinduced synthesis of 2-sulfonylacetonitriles with the insertion of sulfur dioxide under ultraviolet irradiation

Metal-free insertion of sulfur dioxide with aryl iodides and 3-azido-2-methylbut-3-en-2-ol under ultraviolet irradiation at room temperature is achieved, giving rise to 2-(arylsulfonyl)acetonitriles in moderate to good yields. Alkyl iodide is also workable under these conditions. This transformation proceeds smoothly under mild conditions with a broad substrate scope. Various functional groups are compatible including amino, ester, halo, and trifluoromethyl groups. No metal catalyst or additive is needed during the reaction process. Mechanistic studies show that under ultraviolet irradiation, an aryl radical is generated in situ from aryl iodide, which undergoes subsequent sulfonylation via the insertion of sulfur dioxide leading to arylsulfonyl radical intermediates. Then the arylsulfonyl radical reacts with 3-azido-2-methylbut-3-en-2-ol giving rise to the corresponding 2-(arylsulfonyl)acetonitrile.

Synthesis and biological evaluation of triazolothienopyrimidine derivatives as novel HIV-1 replication inhibitors

We identified a novel class of triazolothienopyrimidine (TTPM) compounds as potent HIV-1 replication inhibitors during a high-throughput screening campaign that evaluated more than 200,000 compounds using a cell-based full replication assay. Herein, we report the optimization of the antiviral activity in a cell-based assay system leading to the discovery of aryl-substituted TTPM derivatives (38, 44, and 45), which exhibited significant inhibition of HIV-1 replication with acceptable safety margins. These novel and potent TTPMs could serve as leads for further development.