797050-67-0

Basic information

• Product Name: 1-benzyl-3-(2-hydroxy-4,6-dimethoxynicotinoyl)indole
• Synonyms: 1-benzyl-3-(2-hydroxy-4,6-dimethoxynicotinoyl)indole
• CAS NO: 797050-67-0
• Molecular Weight: 388.423
• Mol File: 797050-67-0.mol

Chemical Properties

• CAS DataBase Reference: 1-benzyl-3-(2-hydroxy-4,6-dimethoxynicotinoyl)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-3-(2-hydroxy-4,6-dimethoxynicotinoyl)indole(797050-67-0)
• EPA Substance Registry System: 1-benzyl-3-(2-hydroxy-4,6-dimethoxynicotinoyl)indole(797050-67-0)

Safety Data

• Hazardous Substances Data: 797050-67-0(Hazardous Substances Data)

Upstream product

• 797050-65-8 1-benzyl-3-(2,4,6-trimethoxynicotinoyl)indole-2-carboxylic acid 
• 151054-77-2 1-benzylindole-2,3-dicarboxylic anhydride 
• 91591-88-7 2,4,6-trimethoxypyridine 
• 797050-66-9 1-benzyl-3-(2,4,6-trimethoxynicotinoyl)indole 

Downstream Products

• 872171-01-2 1-(1-benzyl-3-indolyl)-1-(4-hydroxy-6-methoxy-3-pyridinyl)ethane 
• 872170-98-4 1-benzyl-3-(4,6-dimethoxynicotinoyl)indole 
• 872171-00-1 1-(1-benzyl-3-indolyl)-1-(4-hydroxy-6-methoxy-3-pyridinyl)ethene 
• 872170-99-5 1-benzyl-3-(4-hydroxy-6-methoxynicotinoyl)indole 
• 872171-02-3 1-(1-benzyl-3-indolyl)-1-(6-methoxy-4-trifluoromethanesulfonyloxy-3-pyridinyl)ethane 
• 797050-70-5 (1-benzyl-1H-indol-3-yl)-(4-hydroxy-6-methoxy-2-methyl-pyridin-3-yl)-methanone 
• 797050-69-2 (1-benzyl-1H-indol-3-yl)-(4,6-dimethoxy-2-methyl-pyridin-3-yl)-methanone 

Relevant articles and documents

Synthesis of 3-methoxyellipticine andellipticine by friedel-crafts reaction of indole-2,3-dicarboxylic anhydride and selective demethylation

Reaction of 1-benzylindole-2,3-dicarboxylic anhydride with 2,4,6-trimethoxypyridine in the presence of a Lewis acid gave 1-benzyl-3-(2,4,6-trimethoxynicotinoyl)indole-2-carboxylic acid as the sole product in high yield, which could be changed to 1-benzyl-3-(2,4,6-trimethynicotinoyl)indole. 1-Benzyl-3-(2,4,6-trimethoxynicotinoyl)indole was converted to 3-methoxyellipticine and ellipticine by selective demethylation and triflation of the methoxy group.

Synthesis of 3-methoxyolivacine and olivacine by Friedel-Crafts reaction of indole-2,3-dicarboxylic anhydride with 2,4,6-trimethoxypyridine

1-Benzylindole-2,3-dicarboxylic anhydride (1) was reacted with 2,4,6-trimethoxypyridine in the presence of titanium(IV) chloride to give 3-(2,4,6-trimethoxynicotinoyl)indole-2-carboxylic acid (2) as the sole product in high yield, which could be converted