79722-88-6Relevant academic research and scientific papers
On the Synthesis of 3(5)-Carbomethoxy-4-hetarylpyrazoles
Cativiela, Carlos,Villegas, Maria D. Diaz de,Mayoral, Jose A.,Avenoza, Alberto,Roy, Miguel A.
, p. 851 - 855 (2007/10/02)
3(5)-Carbomethoxy-4-hetarylpyrazoles 3 can be obtained by the aromatization of the corresponding cis-3-benzamido-3-carbomethoxy-4-hetaryl-Δ1-pyrazolines 2 obtained by 1,3-dipolar cycloaddition of diazomethane with methyl Z-2-benzamido-3-hetarylpropenoates 1.An explanation, based on FMO theory, for the different reactivity of the dipolarophiles with diazomethane is given.
Useful Synthesis of α,β-Dehydrotryptophan Derivatives
Moriya, Tamon,Yoneda, Naoto,Miyoshi, Muneji,Matsumoto, Kazuo
, p. 94 - 98 (2007/10/02)
N-Acyl-α,β-dehydrotryptophan (ΔTrp) esters 4a-h were directly synthesized by the reaction of 3--3H-indole (2) with N-acylglycinates 3a-h in resonable yields.Of these, N-formyl-substituted ΔTrp methyl ester (4a) was easily converted into ΔTrp methyl ester (7) in a high yield by acidolysis with dry methanol-hydrogen chloride.Furthermore, 7 was successfully used for the preparation of a dipeptide, N-alanyl-substituted ΔTrp methyl ester (10).
