79729-80-9

Upstream product

• 141-82-2 malonic acid 
• 84518-22-9 2‐methyl‐4‐(2,6,6‐trimethylcyclohex‐1‐en‐1‐yl)butanal 
• 99723-03-2 (Z)-ethyl 4-methyl-6-(2,6,6-trimethylcyclohex-1-en-1-yl)hex-3-enoate 
• 17283-81-7 4-(2,6,6-Trimethyl-cyclohex-1-enyl)-butan-2-on 
• 18665-81-1 (E)-3-methyl-5-(2',6',6'-trimethylcyclohex-1'-en-1'-yl)pent-2-en-1-ol 
• 84817-91-4 4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hex-3ξ-enoic acid 
• 1383536-60-4 2-(2-methyl-4-(2,6,6-trimethylcyclohex-1-enyl)butylidene)malonic acid 

Downstream Products

• 564-20-5 trans-syn-cis norambreinolide 
• 3738-00-9 (3aRS,5aSR,9aSR,9bSR)-dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan 

Relevant academic research and scientific papers

PROCESSES FOR THE PREPARATION OF UNSATURATED ESTERS

The invention provides a process for the preparation of alkyl 4-methyl-6-(2,6,6-trimethylcyclohex-lenyl) hex-3-enoate comprising a single step wherein 2-methyl-4-(2,6,6- trimethylcyclohex-l-en-l-yl)butanal is reacted with monoalkyl malonate.

2-(ALKOXY OR ARYLOXY CARBONYL)-4-METHYL-6-(2,6,6-TRIMETHYLCYCLOHEX-1- ENYL)HEX-2-ENOIC ACID COMPOUNDS, ITS PREPARATION AND USE

Compounds of the formula 1 wherein, R is hydrogen, alkyl or substituted alkyl, aryl or substituted aryl are useful intermediates in the synthesis of fragrance ingredients such as Ambrox 2.

2-(ALKOXY OR ARYLOXY CARBONYL)-4-METHYL-6-(2,6,6-TRIMETHYLCYCLOHEX-1-ENYL)HEX-2-ENOIC ACID COMPOUNDS, ITS PREPARATION AND USE

Compounds of the formula (1), wherein, R is hydrogen, alkyl or substituted alkyl, aryl or substituted aryl are useful intermediates in the synthesis of fragrance ingredients such as Ambrox (2).

New Syntheses of (+/-)-Ambrox, (+/-)-Ambra Oxide and Their Stereoisomers

New and efficient syntheses of (+/-)-ambrox (1a), (+/-)-ambra oxide (2a) and their stereoisomers (1b, 2b ca. c), amber-like odorous compounds, are described.Starting from dihydro β- and α-ionone (5,12), these substances were obtained in only a few steps via stereoselective acid-catalized cyclization of monocyclodienoic acid (7a ca. b, 11a ca. b, 15a).

SYNTHESIS OF (+/-)-NORAMBREINOLIDE BY CYCLIZATION OF TRANS-β-MONOCYCLOHOMOFARNESIC ACID

Synthesis of norambreinolide by acid-catalized cyclization of trans-β-monocyclohomofarnesic aicd was studied.From the acid norambreinolide was obtained in 57 per cent by catalysis of stannic chloride in dichloromethane at -78 deg C.Isomerization of norambreinolide to norisoambreinolide was observed with a rise of reaction temperature in the presence of stannic chloride.