99723-03-2

Upstream product

• 141-82-2 malonic acid 
• 84518-22-9 2‐methyl‐4‐(2,6,6‐trimethylcyclohex‐1‐en‐1‐yl)butanal 
• 1071-46-1 hydrogen ethyl malonate 
• 1312343-34-2 diethyl 2-(2-methyl-4-(2,6,6-trimethylcyclohex-1-enyl)butylidene)malonate 
• 18665-81-1 (E)-3-methyl-5-(2',6',6'-trimethylcyclohex-1'-en-1'-yl)pent-2-en-1-ol 
• 17283-81-7 4-(2,6,6-Trimethyl-cyclohex-1-enyl)-butan-2-on 
• 64-17-5 ethanol 
• 84817-91-4 4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hex-3ξ-enoic acid 

Downstream Products

• 79729-80-9 (Z)-4-methyl-6-(2,6,6-trimethylcyclohex-1-en-1-yl)hex-3-enoic acid 
• 564-20-5 trans-syn-cis norambreinolide 
• 3738-00-9 (3aRS,5aSR,9aSR,9bSR)-dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan 

Relevant academic research and scientific papers

PROCESSES FOR THE PREPARATION OF UNSATURATED ESTERS

The invention provides a process for the preparation of alkyl 4-methyl-6-(2,6,6-trimethylcyclohex-lenyl) hex-3-enoate comprising a single step wherein 2-methyl-4-(2,6,6- trimethylcyclohex-l-en-l-yl)butanal is reacted with monoalkyl malonate.

ORGANIC COMPOUNDS

A process for the preparation of β,γ-unsaturated-γ,γ-disubstituted esters 1 with high E/Z- and β,γ/α,β-ratios, Formula (1) by reacting at a temperature of between about 130 and 170 degrees centigrade the conjugated malonate Formula (3) with, a group I, II

New Syntheses of (+/-)-Ambrox, (+/-)-Ambra Oxide and Their Stereoisomers

New and efficient syntheses of (+/-)-ambrox (1a), (+/-)-ambra oxide (2a) and their stereoisomers (1b, 2b ca. c), amber-like odorous compounds, are described.Starting from dihydro β- and α-ionone (5,12), these substances were obtained in only a few steps via stereoselective acid-catalized cyclization of monocyclodienoic acid (7a ca. b, 11a ca. b, 15a).

SYNTHESIS OF (+/-)-NORAMBREINOLIDE BY CYCLIZATION OF TRANS-β-MONOCYCLOHOMOFARNESIC ACID

Synthesis of norambreinolide by acid-catalized cyclization of trans-β-monocyclohomofarnesic aicd was studied.From the acid norambreinolide was obtained in 57 per cent by catalysis of stannic chloride in dichloromethane at -78 deg C.Isomerization of norambreinolide to norisoambreinolide was observed with a rise of reaction temperature in the presence of stannic chloride.