79741-33-6

Upstream product

• 65619-17-2 4-isocyanato-4-phenylcyclohexanone, ethylene ketal 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 1071066-97-1 N-(1,4-dioxaspiro-[4,5]-decan-8-yliden)-methanamine 
• 591-51-5 phenyllithium 
• 51509-99-0 8-Phenyl-1,4-dioxaspiro<4.5>decan-8-carbonsaeure 

Downstream Products

• 65619-20-7 4-dimethylamino-4-phenylcyclohexanone 
• 65619-18-3 4-methylamino-4-phenylcyclohexanone, ethylene ketal hydrochloride 
• 77253-85-1 dimethyl-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)amine 
• 720655-30-1 4-(methylamino)-4-phenyl-cyclohexanone 

Relevant academic research and scientific papers

METHOD FOR SYNTHESISING SUBSTITUTED AMINOCYCLOHEXANONE DERIVATIVES

The present invention relates to a method for synthesising substituted aminocyclohexanone derivatives, comprising the following step (b) reaction of a compound of general formula (II) with an organolithium compound to form a compound of general formula (III).

Method for Synthesizing Substituted Aminocyclohexanone Compounds

A method of synthesizing a substituted aminocyclohexanone compound comprising reacting a compound of formula (II) with an organolithium compound to form a compound of formula (III)

Spirocyclic Azaindole Derivatives

The invention relates to substituted azaindole derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted azaindole derivatives for producing medicaments.

4-Amino-4-arylcyclohexanones and Their Derivatives, a Novel Class of Analgesics. 1. Modification of the Aryl Ring

Investigation of central nervous system activity of phenylcyclohexylamines was continued by preparation of "reversed" analogues.Following the unexpected finding of analgesic activity with 1-(dimethylamino)-1-phenylcyclohexylamine, the SAR of the series was investigated.Synthesis starts by double Michael reaction of acrylate on arylacetonitriles.Following cyclization, decarboxylation, ketalization, and saponification, the geminally substituted acid is rearranged to the isocyanate by means of (C6H5O)2PON3.Isocyanates were then converted to the title compounds.Analgesic activity is very sensitive to the nature and position of the substituent on the aromatic ring.The most potent compounds in this series (p-CH3, p-Br) showed 50percent the potency of morphine.Deletion of the ring oxygen abolishes activity.