79767-59-2

Upstream product

• 16257-57-1 methyl (2S,4R)-4-hydroxy-1-(p-tolylsulfonyl)pyrrolidine-2-carboxylate 
• 98-59-9 p-toluenesulfonyl chloride 
• 1076189-60-0 methyl (2S,4R)-4-((methylsulfonyl)oxy)-1-(p-tolylsulfonyl)pyrrolidine-2-carboxylate 
• 51-35-4 4R-4-hydroxyproline 
• 16257-73-1 N,O-ditosyl-trans-4-hydroxy-L-proline methyl ester 
• 20275-18-7 N--trans-4-hydroxy-L-proline 
• 51077-13-5 N-tert-Butyloxycarbonyl-L-prolin 
• 51077-13-5 N-tert-Butyloxycarbonyl-3,4-dehydro-DL-prolin 
• 3395-35-5 DL-3,4-Dehydroproline 
• 186581-53-3 diazomethane 
• 79680-63-0 N-Tosyl-3,4-dehydro-L-prolin 

Downstream Products

• 57849-99-7 N-Tosyl-3,4-epoxy-L-prolin-methylester 

Relevant academic research and scientific papers

Diastereoselective Diboration of Cyclic Alkenes: Application to the Synthesis of Aristeromycin

The Pt-catalyzed diboration of cyclic alkenes is extended to unsaturated heterocycles and bicyclic compounds and can be accomplished in a diastereoselective fashion. The optimal procedures, substrate scope, and diastereoselectivity were investigated, and examples employing both homogeneous and heterogeneous catalysis were examined. Lastly, application to the construction of the nucleoside analog (±)-aristeromycin was conducted.

A highly efficient conversion of primary or secondary alcohols into fluorides with n-perfluorobutanesulfonyl fluoride-tetrabutylammonium triphenyldifluorosilicate

Direct fluorination of primary and secondary alcohols by a combination of perfluoro-1-butanesulfonyl fluoride (PBSF) and tetrabutylammonium triphenyldifluorosilicate (TBAT) under mild conditions provides the corresponding fluorides in high yields. With th

Synthesis of (2R,3R,4S)-2-hydroxymethylpyrrolidine-3,4-diol from (2S)-3,4-dehydroproline derivatives

(2R,3R,4S)-2-Hydroxymethylpyrrolidine-3,4-diol (1,4-dideoxy-1,4-imino-D-ribitol) was synthesized in five steps from N-protected (2S)-3,4-dehydroproline methyl esters.The stereoselective reaction of osmium tetraoxide with dehydroproline derivatives gave hi

Synthesis of Two Naturally Occuring Diastereomeric Dihydroxyprolines: 2,3-trans-3,4-trans-3,4-Dihydroxy-L-proline and 2,3-cis-3,4-trans-3,4-Dihydroxy-L-proline

Starting from 2-pyrrolecarboxylic acid the N-Boc derivative 6 is resolved into its optically active constituents by crystalisation with R(+)-1-(4-nitrophenyl)ethaneamin.The N-tosyl-3,4-dehydro-L-proline methyl ester (L-7) derived from this is converted by