79823-34-0

Usage

InChI:InChI=1/C15H21N3O2/c1-2-20-15(19)12-14(16)18-10-8-17(9-11-18)13-6-4-3-5-7-13/h3-7,12H,2,8-11,16H2,1H3/b14-12+

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 39632-87-6 ethyl 3-amino-3-ethoxypropenoate 
• 109831-72-3 ethyl (2E)-3-amino-3-ethoxyacrylate 

Downstream Products

• 905704-47-4 5-hydroxy-2-(4-phenyl-piperazin-1-yl)-1H-indole-3-carboxylic acid ethyl ester 
• 79823-35-1 5-Methyl-4-phenyl-2-(4-phenyl-1-piperazinyl)-3-pyrrolcarbonsaeure-ethylester 

Relevant academic research and scientific papers

Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase

Compounds that inhibit 5-lipoxygenase (5-LO), the key enzyme in the biosynthesis of leukotrienes (LTs), possess potential for the treatment of inflammatory and allergic diseases as well as of atherosclerosis and cancer. Here we present the design and the

Heterocycles from Nitroalkenes, I. - Pyrroles via Michael Addition of Enamines

The principle of a general pyrrole synthesis via cyclising Michael addition of enamines to nitroalkenes is outlined.Condensation of the nitroalkene 7 with various enamines yields the pyrroles 9, 11, 12, 14, 15, 17, 18, 20, 22, 26, 27, 29, and 31.Reaction of 1-nitro-1,2-diphenylethene and the enamine 8 furnishes the pyrroloisoquinoline 32 while addition of 8 to 1-nitrocyclohexene is followed by ring closure to the indoloisoquinoline 33.The pyrrole 14 can also be prepared by multiple-component syntheses, further examples of which are the syntheses of the pyrroles 35, 36, 37, and 38.Scope and advantages of the presented pyrrole synthesis are discussed.