905704-47-4Relevant academic research and scientific papers
Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase
Landwehr, Jens,George, Sven,Karg, Eva-Maria,Poeckel, Daniel,Steinhilber, Dieter,Troschuetz, Reinhard,Werz, Oliver
, p. 4327 - 4332 (2006)
Compounds that inhibit 5-lipoxygenase (5-LO), the key enzyme in the biosynthesis of leukotrienes (LTs), possess potential for the treatment of inflammatory and allergic diseases as well as of atherosclerosis and cancer. Here we present the design and the
