79838-70-3

Upstream product

• 40925-72-2 2-amino-3-chlorobenzenethiol 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 74125-11-4 zinc salt of 3-chloro-2-amino-benzenethiol 
• 64-18-6 formic acid 
• 79838-67-8 2-amino-3-chloro-2'-(3'-nitro-5'-trifluoromethyl)diphenylsulfide 

Relevant academic research and scientific papers

Potential antimicrobial agents: Trifluoromethyl-10H-phenothiazines and ribofuranosides

The zinc salts of substituted 2-amino benzenethiols, on condensation with 2-chloro-3-nitro-5-trifluoromethyl benzene, in presence of sodium acetate and ethanol and subsequent formylation gave the corresponding 2-formamido-substituted diphenylsulfides. From them substituted 2-trifluoromethyl-10H-phenothiazines have been synthesized via Smiles rearrangement. Ribofuranosides α- and β- anomers were synthesized by the condensation of phenothiazines with sugar in toluene in presence of SnCl4 at 0°C and 155-160°C, respectively.

SYNTHESIS OF 9-SUBSTITUTED 1-NITRO AND 1,7-DISUBSTITUTED PHENOTHIAZINES VIA SMILES REARRANGEMENT

Substituted phenothiazines without nitro group at position-1 have been prepared via Smiles rearrangement of 2-formamido-2'-nitro-3,4'-disubstituted diphenyl sulphides.The latter were obtained by the action of formic acid on 2-amino-2'-nitro-3,4'-disubstit