79839-27-3Relevant academic research and scientific papers
Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors
Bondebjerg, Jon,Fuglsang, Henrik,Valeur, Kirsten Rosendal,Pedersen, John,Naerum, Lars
, p. 3614 - 3617 (2007/10/03)
Using a dipeptide nitrile scaffold we have identified a potent and selective inhibitor of human dipeptidyl peptidase I.
SYNTHESIS AND SOME BIOLOGICAL PROPERTIES OF ANALOGUE OF ANGIOTENSIN WITH MODIFIED PROLINE STRUCTURE
Prochazka, Zdenko,Ancans, Yuris E.,Myshlyakova, Nataliya V.,Ratkevich, Marita P.,Strazda, Gunta M.
, p. 3008 - 3014 (2007/10/02)
The angiotensin analogue was synthesized by fragment condensation employing the azide method.Proline in the position 7 in this analogue and phenylalanine in the position 8 were substituted with 2--3-phenylpropa
Protected Lactam-Bridged Dipeptides for Use as Conformational Constraints in Peptides
Freidinger, Roger M.,Perlow, Debra Schwenk,Veber, Daniel F.
, p. 104 - 109 (2007/10/02)
General methods have been devised for the synthesis of lactam-constrained dipeptide analogues having five-, six-, and seven-membered rings.Three different paths from protected chiral α-amino acids to lactams involving intramolecular alkylation, intramolecular acylation, and insertion of a one carbon unit by condensation with formaldehyde have been utilized.The first two methods produce chiral products stereospecifically, but considerable racemization occurs in the third route which leads to a 4-oxo-5-amino-1,3-thiazine (13).The products are prepared in good yield and have protecting groups making them suitable for incorporation into higher peptides by methods commonly used.
